Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 'Ser-15' phosphorylation and nuclear accumulation, which causes cell cycle arrest.
Down-regulated in breast cancer cell lines.
Belongs to the BANP/SMAR1 family. Contains 1 BEN domain.
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human lung carcinoma (left) and mouse renal cell carcinoma (right) tissues labelling BANP with ab72076 at 1/5000 (0.2µg/ml). Setection: DAB.
Western blot - BANP antibody (ab72076)
All lanes : Anti-BANP antibody (ab72076) at 0.1 µg/ml
Lane 1 : Nuclear extract from HeLa cells at 5 µg Lane 2 : Nuclear extract from HeLa cells at 20 µg