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功能
Plays fundamental roles in nuclear assembly, chromatin organization, gene expression and gonad development. May potently compress chromatin structure and be involved in membrane recruitment and chromatin decondensation during nuclear assembly. Contains 2 non-specific dsDNA-binding sites which may promote DNA cross-bridging. Exploited by retroviruses for inhibiting self-destructing autointegration of retroviral DNA, thereby promoting integration of viral DNA into the host chromosome. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD.
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组织特异性
Widely expressed. Expressed in colon, brain, heart, kidney, liver, lung, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen and testis. Not detected in thymus and peripheral blood leukocytes.
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序列相似性
Belongs to the BAF family.
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结构域
Has a helix-hairpin-helix (HhH) structural motif conserved among proteins that bind non-specifically to DNA.
LEM domain proteins bind centrally on the BAF dimer, whereas DNA binds to the left and right sides.
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翻译后修饰
Partially phosphorylated on serine. Ser-4 phosphorylation may block BAF ability to promote EMD binding to lamins in vitro. Non phosphorylated BAF seems to enhances binding between EMD and LMNA.
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细胞定位
Nucleus. Cytoplasm. Chromosome. Significantly enriched at the nuclear inner membrane, diffusely throughout the nucleus during interphase and concentrated at the chromosomes during the M-phase. May be included in HIV-1 virions via its interaction with viral GAG polyprotein.
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Information by UniProt
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数据库链接
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别名
- BAF antibody
- BAF_HUMAN antibody
- BANF 1 antibody
- BANF1 antibody
- Barrier to autointegration factor 1 antibody
- Barrier to autointegration factor antibody
- Barrier-to-autointegration factor antibody
- BCRG 1 antibody
- BCRG1 antibody
- BCRP 1 antibody
- BCRP1 antibody
- Breakpoint cluster region protein 1 antibody
- D14S1460 antibody
- MGC111161 antibody
- NGPS antibody
see all