Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
Contains 5 BAG domains.
The fifth BAG domain is responsible for the interaction with HSP70 nucleotide-binding domain.
Bruchmann A et al. Bcl-2 associated athanogene 5 (Bag5) is overexpressed in prostate cancer and inhibits ER-stress induced apoptosis. BMC Cancer13:96 (2013).
Read more (PubMed: 23448667) »