概述

  • 产品名称Anti-Bag3抗体
    参阅全部 Bag3 一抗
  • 描述
    山羊多克隆抗体to Bag3
  • 经测试应用适用于: IP, WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide: SSMTDTPGNPAAP, corresponding to C terminal amino acids 563-575 of Human Bag3.

  • 阳性对照
    • Human skeletal muscle lysates.
  • 常规说明GenBank Accession Number – NP_004272

性能

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应用

Our Abpromise guarantee covers the use of ab5898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at an assay dependent concentration. PubMed: 23341456
WB Use a concentration of 0.1 - 0.3 µg/ml. Can be blocked with Human Bag3 peptide (ab23111).
Approx 85kDa band observed in Human skeletal muscle lysates (calculated MW of 61.6kDa according to NP_004272.2). The observed molecular weight corresponds to earlier findings in literature with different antibodies (Iwasaki et al, Cancer Res. 2007 Nov 1;67(21):10252-9. PMID: 17974966).

靶标

  • 功能Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
  • 疾病相关Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
  • 序列相似性Contains 1 BAG domain.
    Contains 2 WW domains.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BAG 3 antibody
    • BAG family molecular chaperone regulator 3 antibody
    • BAG-3 antibody
    • Bag3 antibody
    • BAG3_HUMAN antibody
    • Bcl 2 binding protein antibody
    • Bcl-2-associated athanogene 3 antibody
    • Bcl-2-binding protein Bis antibody
    • BCL2 associated athanogene 3 antibody
    • BCL2 binding athanogene 3 antibody
    • BIS antibody
    • CAIR 1 antibody
    • Docking protein CAIR 1 antibody
    • Docking protein CAIR-1 antibody
    • MFM6 antibody
    see all

Anti-Bag3 antibody (ab5898)参考文献

This product has been referenced in:
  • Boiani M  et al. The stress protein BAG3 stabilizes Mcl-1 protein and promotes survival of cancer cells and resistance to antagonist ABT-737. J Biol Chem 288:6980-90 (2013). IP ; Human . Read more (PubMed: 23341456) »

See 1 Publication for this product

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Thank you for providing more information about your protocol. We would like to emphasize that this is a Fast-Track antibody and not fully characterized yet. Please take a look at the Terms and Conditions for Fast-Track products. We cannot guarant...

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