概述

  • 产品名称Anti-Bag3抗体
    参阅全部 Bag3 一抗
  • 描述
    山羊多克隆抗体to Bag3
  • 经测试应用适用于: WB, IHC-P, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide:

    C-SSMTDTPGNPAAP

    , corresponding to C terminal amino acids 563-575 of Human Bag3.

  • 阳性对照
    • Human Heart, Human Skeletal Muscle and Human Placenta tissue

性能

应用

Our Abpromise guarantee covers the use of ab112016 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.1 - 0.3 mg/ml. Predicted molecular weight: 62 kDa.
IHC-P Use a concentration of 3.75 µg/ml.
ELISA 1/8000.

靶标

  • 功能Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.
  • 疾病相关Defects in BAG3 are the cause of myopathy myofibrillar BAG3-related (MFM-BAG3) [MIM:612954]. A neuromuscular disorder that results in early-onset, severe, progressive, diffuse muscle weakness associated with cardiomyopathy, severe respiratory insufficiency during adolescence, and a rigid spine in some patients. At ultrastructural level, muscle fibers display structural alterations consisting of replacement of the normal myofibrillar markings by small, dense granules, or larger hyaline masses, or amorphous material.
  • 序列相似性Contains 1 BAG domain.
    Contains 2 WW domains.
  • Information by UniProt
  • 数据库链接
  • 别名
    • BAG 3 antibody
    • BAG family molecular chaperone regulator 3 antibody
    • BAG-3 antibody
    • Bag3 antibody
    • BAG3_HUMAN antibody
    • Bcl 2 binding protein antibody
    • Bcl-2-associated athanogene 3 antibody
    • Bcl-2-binding protein Bis antibody
    • BCL2 associated athanogene 3 antibody
    • BCL2 binding athanogene 3 antibody
    • BIS antibody
    • CAIR 1 antibody
    • Docking protein CAIR 1 antibody
    • Docking protein CAIR-1 antibody
    • MFM6 antibody
    see all

Anti-Bag3 antibody 图像

  • Immunohistochemical analysis of Bag3 expression in formalin-fixed, paraffin-embedded Human heart tissue using ab112016 at 3.75 µg/ml.
  • Immunohistochemical analysis of Bag3 expression in formalin-fixed, paraffin-embedded Human skeletal muscle tissue using ab112016 at 3.75 µg/ml.
  • Immunohistochemical analysis of Bag3 expression in formalin-fixed, paraffin-embedded Human placenta tissue using ab112016 at 3.75 µg/ml.

Anti-Bag3 antibody (ab112016)参考文献

ab112016 has not yet been referenced specifically in any publications.

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