Anti-BAFF Receptor抗体[11C1] (ab16232)

概述

  • 产品名称Anti-BAFF Receptor抗体[11C1]
    参阅全部 BAFF Receptor 一抗
  • 描述
    小鼠单克隆抗体[11C1] to BAFF Receptor
  • 经测试应用适用于: IHC-P, Flow Cyt, IHC-Frmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Tissue/ cell preparation (Human) - human BAFF Receptor transfected mouse B cell lymphoma L1.2 cells.

  • 阳性对照
    • IHC-P: human tonsil FACS: CD19+ B cells from tonsil.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号11C1
  • 骨髓瘤Sp2/0
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab16232 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P
Flow Cyt
IHC-Fr
  • 应用说明Flow Cyt: Use at an assay dependent dilution.
    IHC-Fr: Use at an assay dependent dilution.
    IHC-P: Use at an assay dependent dilution. Antigen retrieval with EDTA based solution (pH9.0) and heat.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能B-cell receptor specific for TNFSF13B/TALL1/BAFF/BLyS. Promotes the survival of mature B-cells and the B-cell response.
    • 组织特异性Highly expressed in spleen and lymph node, and in resting B-cells. Detected at lower levels in activated B-cells, resting CD4+ T-cells, in thymus and peripheral blood leukocytes.
    • 疾病相关Defects in TNFRSF13C are the cause of immunodeficiency common variable type 4 (CVID4) [MIM:613494]; also called antibody deficiency due to BAFFR defect. CVID4 is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B cells is usually in the normal range, but can be low.
    • 序列相似性Contains 1 TNFR-Cys repeat.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • B cell activating factor receptor antibody
      • B-cell-activating factor receptor antibody
      • BAFF R antibody
      • BAFF receptor antibody
      • BAFF-R antibody
      • BAFFR antibody
      • BLyS receptor 3 antibody
      • BlySR3 antibody
      • BR 3 antibody
      • BR3 antibody
      • BROMIX antibody
      • CD 268 antibody
      • CD268 antibody
      • CD268 antigen antibody
      • CVID4 antibody
      • MGC138235 antibody
      • OTTHUMP00000028746 antibody
      • Prolixin antibody
      • TNFRSF 13C antibody
      • Tnfrsf13c antibody
      • TR13C_HUMAN antibody
      • Tumor necrosis factor receptor subunit member 13C antibody
      • Tumor necrosis factor receptor superfamily member 13C antibody
      see all

    Anti-BAFF Receptor antibody [11C1] 图像

    • Immunohistochemistry staining of human tonsil with ab16232, showing intense staining of B cell follicles and weaker staining on GC. Magnification X200.
    • FACS analysis of B cells performed by gating on CD19+ B cells from tonsil.

    Anti-BAFF Receptor antibody [11C1] (ab16232)参考文献

    This product has been referenced in:
    • Chong BF  et al. Differential expression of BAFF and its receptors in discoid lupus erythematosus patients. J Dermatol Sci N/A:N/A (2013). Human . Read more (PubMed: 24315762) »
    • Di Carlo E  et al. The lack of epithelial interleukin-7 and BAFF/BLyS gene expression in prostate cancer as a possible mechanism of tumor escape from immunosurveillance. Clin Cancer Res 15:2979-87 (2009). IHC-P ; Human . Read more (PubMed: 19366834) »

    See all 4 Publications for this product

    Product Wall

    According to our records, ab16081 and ab16232 was proving difficult to use when staining spleen and aorta tissues presumably in immunohistochemistry and we were in contact in order to help resolve the issue.
    Looking at our correspondence, it appea...

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    I am sorry to hear that you have experienced difficulties with two of our products in the past. However, because we carry over 90,000 products, it isn't feasible for us to keep small sample sizes of our products.
    We are happy to reassure our custo...

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    Thank you for your reply.

    I am sorry that the vials you received did not contain the full amount of the product and I apologize for the inconvenience. As requested, I have issued a free of charge replacement vials of ab16081 and ab16232 with...

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    I'm afraid the the epitope for ab16232 has not been mapped. Sorry I couldn't help you more on this occasion,

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"