概述

描述

  • 性质Synthetic

技术指标

Our Abpromise guarantee covers the use of ab8391 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • 应用

    Blocking

  • 形式Liquid
  • Concentration information loading...

制备和贮存

  • 稳定性和存储

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

常规信息

  • 别名
    • ALP 56
    • ALP56
    • Asp 1
    • ASP1
    • ASP21
    • Aspartic Like Protease 56kDa
    • Aspartic-like protease 56 kDa
    • Aspartyl protease 1
    • BACE 2
    • Bace2
    • BACE2_HUMAN
    • Beta Secretase 2
    • Beta Site Amyloid Beta A4 Precursor Protein Cleaving Enzyme 2
    • Beta-secretase 2
    • Beta-site amyloid precursor protein cleaving enzyme 2
    • Beta-site APP cleaving enzyme 2
    • Down region aspartic protease
    • Downs Syndrome Region Aspartic Protease
    • DRAP
    • Memapsin 1
    • Memapsin-1
    • Membrane associated aspartic protease 1
    • Membrane-associated aspartic protease 1
    • Theta-secretase
    see all
  • 功能Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
  • 组织特异性Brain. Present in neurons within the hippocampus, frontal cortex and temporal cortex (at protein level). Expressed at low levels in most peripheral tissues and at higher levels in colon, kidney, pancreas, placenta, prostate, stomach and trachea. Expressed at low levels in the brain. Found in spinal cord, medulla oblongata, substantia nigra and locus coruleus. Expressed in the ductal epithelium of both normal and malignant prostate.
  • 序列相似性Belongs to the peptidase A1 family.
  • 翻译后修饰Undergoes autoproteolytic cleavage.
    Glycosylated.
  • 细胞定位Membrane. Golgi apparatus. Endoplasmic reticulum. Endosome. Cell surface.
  • Information by UniProt

BACE2 peptide (ab8391)参考文献

ab8391 has not yet been referenced specifically in any publications.

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