概述

  • 产品名称Anti-BACE1抗体
    参阅全部 BACE1 一抗
  • 描述
    兔多克隆抗体to BACE1
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Mouse, Human
  • 免疫原

    KLH conjugated synthetic peptide corresponding to amino acid residues surrounding S498 of human BACE1.

  • 阳性对照
    • Mouse cerebellum tissue lysates

性能

应用

Our Abpromise guarantee covers the use of ab76019 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/1000.
    WB: 1/50 - 1/100. Detects bands of approximately 28, 34, 56 and 60 kDa (predicted molecular weight: 56 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
    • 组织特异性Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.
    • 序列相似性Belongs to the peptidase A1 family.
    • 结构域The transmembrane domain is necessary for its activity. It determines its late Golgi localization and access to its substrate, APP.
    • 翻译后修饰Glycosylated.
    • 细胞定位Membrane. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface.
    • Information by UniProt
    • 数据库链接
    • 别名
      • APP beta secretase antibody
      • Asp 2 antibody
      • ASP2 antibody
      • Aspartyl protease 2 antibody
      • BACE 1 antibody
      • BACE antibody
      • BACE1 antibody
      • BACE1_HUMAN antibody
      • Beta secretase 1 antibody
      • Beta secretase antibody
      • Beta site amyloid beta A4 precursor protein cleaving enzyme antibody
      • Beta site amyloid precursor protein cleaving enzyme 1 antibody
      • Beta site amyloid precursor protein cleaving enzyme antibody
      • Beta site APP cleaving enzyme 1 antibody
      • Beta site APP cleaving enzyme antibody
      • Beta-secretase 1 antibody
      • Beta-site amyloid precursor protein cleaving enzyme 1 antibody
      • Beta-site APP cleaving enzyme 1 antibody
      • FLJ90568 antibody
      • HSPC104 antibody
      • Memapsin 2 antibody
      • Memapsin-2 antibody
      • Memapsin2 antibody
      • Membrane associated aspartic protease 2 antibody
      • Membrane-associated aspartic protease 2 antibody
      • Transmembrane aspartic proteinase Asp2 antibody
      see all

    Anti-BACE1 antibody 图像

    • Anti-BACE1 antibody (ab76019) at 1/50 dilution + Mouse cerebellum tissue lysates at 35 µg

      Predicted band size : 56 kDa
      Observed band size : 56 kDa
      Additional bands at : 28 kDa,34 kDa,60 kDa. We are unsure as to the identity of these extra bands.

    Anti-BACE1 antibody (ab76019)参考文献

    ab76019 has not yet been referenced specifically in any publications.

    Product Wall

    There are currently no Abreviews or Questions for ab76019.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"