概述

  • 产品名称Anti-B3GAT3抗体
    参阅全部 B3GAT3 一抗
  • 描述
    小鼠多克隆抗体to B3GAT3
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length protein, corresponding to amino acids 1-335 of Human B3GAT3

  • 阳性对照
    • Transfected 293T cell line

性能

应用

Our Abpromise guarantee covers the use of ab68026 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 37 kDa (predicted molecular weight: 37 kDa).

靶标

  • 功能Glycosaminoglycans biosynthesis. Involved in forming the linkage tetrasaccharide present in heparan sulfate and chondroitin sulfate. Transfers a glucuronic acid moiety from the uridine diphosphate-glucuronic acid (UDP-GlcUA) to the common linkage region trisaccharide Gal-beta-1,3-Gal-beta-1,4-Xyl covalently bound to a Ser residue at the glycosaminylglycan attachment site of proteoglycans. Can also play a role in the biosynthesis of l2/HNK-1 carbohydrate epitope on glycoproteins. Shows strict specificity for Gal-beta-1,3-Gal-beta-1,4-Xyl, exhibiting negligible incorporation into other galactoside substrates including Galbeta1-3Gal beta1-O-benzyl, Galbeta1-4GlcNAc and Galbeta1-4Glc.
  • 组织特异性Ubiquitous (but weakly expressed in all tissues examined).
  • 通路Protein modification; protein glycosylation.
  • 疾病相关Defects in B3GAT3 are the cause of multiple joint dislocations short stature craniofacial dysmorphism and congenital heart defects (JDSSDHD) [MIM:245600]. An autosomal recessive disease characterized by dysmorphic facies, bilateral dislocations of the elbows, hips, and knees, clubfeet, and short stature, as well as cardiovascular defects.
  • 序列相似性Belongs to the glycosyltransferase 43 family.
  • 翻译后修饰N-glycosylated.
  • 细胞定位Golgi apparatus membrane. Golgi apparatus > cis-Golgi network.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 3-Gal-R glucuronyltransferase antibody
    • 3-glucuronyltransferase 3 antibody
    • B3GA3_HUMAN antibody
    • B3GAT3 antibody
    • Beta 1,3 glucuronyltransferase 3 (glucuronosyltransferase I) antibody
    • Beta 1,3 glucuronyltransferase 3 antibody
    • Beta-1 antibody
    • EC 2.4.1.135 antibody
    • Galactosylgalactosylxylosylprotein 3 beta glucuronosyltransferase 3 antibody
    • Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 antibody
    • GlcAT-I antibody
    • GLCATI antibody
    • glcUAT I antibody
    • GlcUAT-I antibody
    • GlcUATI antibody
    • Glucuronosyltransferase I antibody
    • Sqv 8 like protein antibody
    • UDP GlcUA:Gal beta 1,3 Gal R glucuronyltransferase antibody
    • UDP GlcUA:Gal beta 1,3 GalR glucuronyltransferase antibody
    • UDP-GlcUA:Gal beta-1 antibody
    see all

Anti-B3GAT3 antibody 图像

  • All lanes : Anti-B3GAT3 antibody (ab68026) at 1/500 dilution

    Lane 1 : B3GAT3 transfected 293T cell lysate
    Lane 2 : Non transfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat Anti-Mouse IgG (H&L)-HRP Conjugate secondary antibody at 1/2500 dilution
    Developed using the ECL technique

    Predicted band size : 37 kDa
    Observed band size : 37 kDa

Anti-B3GAT3 antibody (ab68026)参考文献

ab68026 has not yet been referenced specifically in any publications.

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