Anti-Axl抗体[MM0098-2N33] (ab89224)
Key features and details
- Mouse monoclonal [MM0098-2N33] to Axl
- Suitable for: ICC/IF
- Reacts with: African green monkey
- Isotype: IgG1
选择批间可重复性更高的重组抗体
- 研究可靠 —— 各批次间结果一致且可重复
- 长期批量供应 —— 采用重组技术,可实现快速生产
- 首次实验即可成功 —— 经过大量验证确认了特异性
- 符合伦理标准 —— 产品不含动物成分
概述
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产品名称
Anti-Axl抗体[MM0098-2N33]
参阅全部 Axl 一抗 -
描述
小鼠单克隆抗体[MM0098-2N33] to Axl -
宿主
Mouse -
经测试应用
适用于: ICC/IFmore details -
种属反应性
与反应: African green monkey -
免疫原
Human recombinant Axl (extracellular region).
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常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
存储溶液
Constituent: PBS -
Concentration information loading...
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纯度
Protein G purified -
纯化说明
The IgG fraction of culture supernatant was purified by Protein G affinity chromatography. -
克隆
单克隆 -
克隆编号
MM0098-2N33 -
同种型
IgG1 -
研究领域
相关产品
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Compatible Secondaries
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Conjugation kits
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab89224于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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ICC/IF | (1) |
Use at an assay dependent concentration.
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说明 |
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ICC/IF
Use at an assay dependent concentration. |
靶标
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功能
May function as a signal transducer between specific cell types of mesodermal origin. In case of filovirus infection, seems to function as a cell entry factor. -
组织特异性
Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue. -
序列相似性
Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.
Contains 2 fibronectin type-III domains.
Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Contains 1 protein kinase domain. -
细胞定位
Membrane. - Information by UniProt
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别名
- Adhesion related kinase antibody
- AI323647 antibody
- Ark antibody
see all
图片
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ab89224 staining Axl in african green monkey CV1 cells by Immunocytochemistry/ Immunofluorescence. The cells were fixed in 4% paraformaldehyde and then blocked using 5% serum for 1 hour at 22°C. Samples were then incubated with primary antibody at 1/100 for 16 hours at 4°C. The secondary antibody used was a donkey anti-mouse IgG conjugated to Alexa Fluor® 546 (red) used at a 1/400 dilution. DAPI was used to counterstain nuclei.
数据表及文件
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SDS download
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Datasheet download
文献 (6)
ab89224 被引用在 6 文献中.
- Kong L et al. Qigesan inhibits esophageal cancer cell invasion and migration by inhibiting Gas6/Axl-induced epithelial-mesenchymal transition. Aging (Albany NY) 12:9714-9725 (2020). PubMed: 32432570
- Kong L et al. Qigesan reduces the motility of esophageal cancer cells via inhibiting Gas6/Axl and NF-?B expression. Biosci Rep 39:N/A (2019). PubMed: 31110076
- Koopman LA et al. Enapotamab vedotin, an AXL-specific antibody-drug conjugate, shows preclinical antitumor activity in non-small cell lung cancer. JCI Insight 4:N/A (2019). PubMed: 31600169
- Kwon JY et al. Relevance of placental type I interferon beta regulation for pregnancy success. Cell Mol Immunol N/A:N/A (2018). PubMed: 29907882
- Antony J et al. The tumour suppressor OPCML promotes AXL inactivation by the phosphatase PTPRG in ovarian cancer. EMBO Rep 19:N/A (2018). PubMed: 29907679
- Kong X et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature 550:270-274 (2017). WB . PubMed: 28976960