Anti-Avian Influenza A Nucleoprotein抗体(ab119975)

概述

  • 产品名称Anti-Avian Influenza A Nucleoprotein抗体
  • 描述
    兔多克隆抗体to Avian Influenza A Nucleoprotein
  • 特异性ab119975 crossreacts with Avian Influenza A Nucleoprotein in Avian and Chicken.
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    与反应: Chicken
  • 免疫原

    Avian Influenza A Nucleoprotein (H5N1).

性能

应用

Our Abpromise guarantee covers the use of ab119975 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent dilution.

靶标

  • 相关性Encapsidates the negative strand viral RNA, protecting it from nucleases. The encapsidated genomic RNA is termed the ribonucleoprotein (RNP) and serves as template for transcription and replication. The RNP needs to be localized in the nucleus to start an infectious cycle, but is too large to diffuse through the nuclear pore complex. NP comprises at least 2 nuclear localization signals and is responsible of the active RNP import into the nucleus through the cellular importin alpha/beta pathway. Later in the infection, nucleus export of RNP are mediated through viral proteins NEP interacting with M1 which binds nucleoproteins. It is possible that the nucleoprotein binds directly exportin-1 (XPO1) and plays an active role in RNP nuclear export. M1 interaction with RNP seems to hide nucleoprotein's nuclear localization signals. Soon after a virion infects a new cell, M1 dissociates from the RNP under acidification of the virion driven by M2 protein. Dissociation of M1 from RNP unmask nucleoprotein's nuclear localization signals, targeting the RNP to the nucleus.
  • 细胞定位Virion. Host nucleus.
  • 别名
    • Avian Influenza A NP antibody
    • NP antibody
    • Nucleocapsid protein antibody
    • Nucleoprotein antibody

Anti-Avian Influenza A Nucleoprotein antibody (ab119975)参考文献

ab119975 has not yet been referenced specifically in any publications.

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