Anti-Avian Influenza A Neuraminidase抗体(ab21305)

概述

  • 产品名称Anti-Avian Influenza A Neuraminidase抗体
    参阅全部 Avian Influenza A Neuraminidase 一抗
  • 描述
    兔多克隆抗体to Avian Influenza A Neuraminidase
  • 经测试应用适用于: ELISAmore details
  • 种属反应性
    Reacts with Avian Influenza A. Not yet tested in other species.
  • 免疫原

    Synthetic peptide corresponding to 16 amino acids in the middle of the Neuraminidase protein. Efforts were made to use relatively conserved regions as the antigen.

性能

应用

Our Abpromise guarantee covers the use of ab21305 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
  • 应用说明ELISA: Use at a concentration of 1 µg/ml, detects 10 ng of free peptide.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 相关性Catalyzes the removal of terminal sialic acid residues from viral and cellular glycoconjugates. Cleaves off the terminal sialic acids on the glycosylated HA during virus budding to facilitate virus release. Additionally helps virus spread through the circulation by further removing sialic acids from the cell surface. These cleavages prevent self-aggregation and ensure the efficient spread of the progeny virus from cell to cell. Otherwise, infection would be limited to one round of replication. Described as a receptor-destroying enzyme because it cleaves a terminal sialic acid from the cellular receptors. May facilitate viral invasion of the upper airways by cleaving the sialic acid moities on the mucin of the airway epithelial cells. Likely to plays a role in the budding process through its association with lipid rafts during intracellular transport. May additionally display a raft-association independent effect on budding. Plays a role in the determination of host range restriction on replication and virulence. Sialidase activity in late endosome/lysosome traffic seems to enhance virus replication.
    • 细胞定位Cell Membrane; Virion membrane. Apical cell membrane; Single-pass type II membrane protein (By similarity).
    • 别名
      • NA antibody
      • Neuraminidase antibody

    Anti-Avian Influenza A Neuraminidase antibody (ab21305)参考文献

    This product has been referenced in:
    • Wu CY  et al. Mammalian expression of virus-like particles for advanced mimicry of authentic influenza virus. PLoS One 5:e9784 (2010). WB, ICC/IF . Read more (PubMed: 20339535) »
    • Su CY  et al. In vitro evaluation of neuraminidase inhibitors using the neuraminidase-dependent release assay of hemagglutinin-pseudotyped viruses. Antiviral Res 79:199-205 (2008). Read more (PubMed: 18453004) »

    See all 2 Publications for this product

    Product Wall

    Thank you for kindly providing the sequence. This has been checked, and has the following percentage alignment with the following two antibodies: ab21304 Avian Influenza A Neuraminidase antibody: 80% ab21305 Avian Influenza A Neuraminidase ...

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    Thank you for your enquiry. Unfortunately, the immunogen sequences for ab21292, ab21297, ab21304 and ab21305 are proprietary. However, I can give you a range from which we selected the peptides. ab21305 - residues 150-200 ab21304 – residues 4...

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    Thank you for your enquiry and your interest in our products. This product should detect the protein. Unfortunately, we have only been able to test the antibody against the immunogen peptide in ELISA.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"