概述

  • 产品名称Anti-ATXN10抗体
    参阅全部 ATXN10 一抗
  • 描述
    兔多克隆抗体to ATXN10
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Rabbit, Guinea pig, Cow, Dog
  • 免疫原

    Synthetic peptide corresponding to a region within N terminal amino acids 8-57 (PARLSGVMVP APIQDLEALR ALTALFKEQR NRETAPRTIF QRVLDILKKS) of Human ATXN10 (NM_013236).

  • 阳性对照
    • 293T cell lysate

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Constituents: 97% PBS, 2% Sucrose
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab116528 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能Necessary for the survival of cerebellar neurons (By similarity). Induces neuritogenesis by activating the Ras-MAP kinase pathway (By similarity). May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis.
  • 组织特异性Expressed in the central nervous system.
  • 疾病相关Defects in ATXN10 are the cause of spinocerebellar ataxia type 10 (SCA10) [MIM:603516]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA10 is an autosomal dominant cerebellar ataxia (ADCA).
  • 序列相似性Belongs to the ataxin-10 family.
  • 细胞定位Cytoplasm > perinuclear region.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Ataxin 10 antibody
    • Ataxin-10 antibody
    • ATX10_HUMAN antibody
    • Atxn10 antibody
    • Brain protein E46 homolog antibody
    • E46L antibody
    • FLJ37990 antibody
    • HUMEEP antibody
    • Like mouse brain protein E46 antibody
    • OTTHUMP00000197383 antibody
    • SCA10 antibody
    • Spinocerebellar ataxia 10 antibody
    • Spinocerebellar ataxia type 10 protein antibody
    see all

Anti-ATXN10 antibody 图像

  • Anti-ATXN10 antibody (ab116528) at 1 µg/ml + 293T cell lysate at 10 µg

    Predicted band size : 53 kDa

Anti-ATXN10 antibody (ab116528)参考文献

ab116528 has not yet been referenced specifically in any publications.

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