概述

  • 产品名称Anti-ATP7b抗体
    参阅全部 ATP7b 一抗
  • 描述
    小鼠单克隆抗体to ATP7b
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: QLKCYKKPDL ERYEAQAHGH MKPLTASQVS VHIGMDDRWR DSPRATPWDQ VSYVSQVSLS SLTSDKPSRH SAAADDDGDK WSLLLNGRDE EQYI, corresponding to amino acids 1372-1466 of Human ATP7b

性能

应用

Our Abpromise guarantee covers the use of ab54792 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Involved in the export of copper out of the cells, such as the efflux of hepatic copper into the bile.
    • 组织特异性Most abundant in liver and kidney and also found in brain. Isoform 2 is expressed in brain but not in liver. The cleaved form WND/140 kDa is found in liver cell lines and other tissues.
    • 疾病相关Defects in ATP7B are the cause of Wilson disease (WD) [MIM:277900]. WD is an autosomal recessive disorder of copper metabolism in which copper cannot be incorporated into ceruloplasmin in liver, and cannot be excreted from the liver into the bile. Copper accumulates in the liver and subsequently in the brain and kidney. The disease is characterized by neurologic manifestations and signs of cirrhosis.
    • 序列相似性Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.
      Contains 6 HMA domains.
    • 翻译后修饰Isoform 1 may be proteolytically cleaved at the N-terminus to produce the WND/140 kDa form.
    • 细胞定位Cytoplasm; Mitochondrion and Golgi apparatus > trans-Golgi network membrane. Predominantly found in the trans-Golgi network (TGN). Not redistributed to the plasma membrane in response to elevated copper levels.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ATP7B antibody
      • ATP7B_HUMAN antibody
      • ATPase, Cu(2+) transporting, beta polypeptide antibody
      • ATPase, Cu++ transporting, beta polypeptide antibody
      • Copper pump 2 antibody
      • Copper transporting ATPase 2 antibody
      • PWD antibody
      • Toxic milk antibody
      • tx antibody
      • WC1 antibody
      • WD antibody
      • Wilson disease associated protein antibody
      • Wilson disease-associated protein antibody
      • WND antibody
      • WND/140 kDa antibody
      see all

    Anti-ATP7b antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54792 ATP7b antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    Anti-ATP7b antibody (ab54792)参考文献

    ab54792 has not yet been referenced specifically in any publications.

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