概述

  • 产品名称Anti-ATP6V1B1抗体
    参阅全部 ATP6V1B1 一抗
  • 描述
    兔多克隆抗体to ATP6V1B1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide derived from the C terminal of Human ATP6V1B1.

  • 阳性对照
    • Human breast carcinoma tissue; Extracts from HepG2 cells

性能

应用

Our Abpromise guarantee covers the use of ab110752 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Predicted molecular weight: 57 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

靶标

  • 功能Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells.
  • 组织特异性Expressed in the cochlea and endolymphatic sac.
  • 疾病相关Defects in ATP6V1B1 are the cause of distal renal tubular acidosis with deafness (dRTA-D) [MIM:267300]. Inheritance is autosomal recessive. Patients with recessive dRTA are severely affected, presenting with either acute illness or growth failure at a young age, and bilateral sensorineural deafness. Other features include low serum K(+) due to renal potassium wasting, and elevated urinary calcium. If untreated, this acidosis may result in dissolution of bone, leading to osteomalacia and rickets. Renal deposition of calcium salts (nephrocalcinosis) and renal stone formation commonly occur.
  • 序列相似性Belongs to the ATPase alpha/beta chains family.
  • 结构域The PDZ-binding motif mediates interactions with SLC9A3R1 and SCL4A7.
  • 细胞定位Endomembrane system. Endomembrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Atp6b1 antibody
    • ATP6V1B1 antibody
    • ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 1 antibody
    • ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B, isoform 1 antibody
    • ATPase, H+ transporting, V1 subunit B, isoform 1 antibody
    • Endomembrane proton pump 58 kDa subunit antibody
    • H(+) transporting two sector ATPase 58kD subunit antibody
    • H+ ATPase beta 1 subunit antibody
    • kidney isoform antibody
    • Lysosomal 56/58kDa antibody
    • MGC32642 antibody
    • RTA1B antibody
    • V ATPase B1 subunit antibody
    • V type proton ATPase subunit B kidney isoform antibody
    • V type proton ATPase subunit B, kidney isoform antibody
    • V-ATPase subunit B 1 antibody
    • V-type proton ATPase subunit B antibody
    • Vacuolar proton pump 3 antibody
    • Vacuolar proton pump subunit 3 antibody
    • Vacuolar proton pump subunit B 1 antibody
    • VATB antibody
    • VATB1_HUMAN antibody
    • VMA2 antibody
    • Vpp 3 antibody
    • Vpp3 antibody
    see all

Anti-ATP6V1B1 antibody 图像

  • ab110752, at 1/50 dilution, staining ATP6V1B1 in paraffin-embedded Human breast carcinoma tissue. Right panel is also in the presence of immunising peptide.
  • All lanes : Anti-ATP6V1B1 antibody (ab110752) at 1/500 dilution

    Lane 1 : Extracts from HepG2 cells
    Lane 2 : Extracts from HepG2 cells with immunising peptide at 10 µg

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 57 kDa

Anti-ATP6V1B1 antibody (ab110752)参考文献

ab110752 has not yet been referenced specifically in any publications.

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