概述

  • 产品名称Anti-ATP6V0A2抗体
    参阅全部 ATP6V0A2 一抗
  • 描述
    兔多克隆抗体to ATP6V0A2
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment corresponding to a region within amino acids 156-404 of Human ATP6V0A2 (NP_036595).

  • 阳性对照
    • 293T, A431 and H1299 whole cell lysates; DLD1 xenograft; HeLa, HepG2, MOLT4 and Raji cell lysates

性能

应用

Our Abpromise guarantee covers the use of ab96803 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 98 kDa.
IHC-P 1/100 - 1/500.

靶标

  • 功能Part of the proton channel of V-ATPases. Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH.
  • 疾病相关Defects in ATP6V0A2 are the cause of cutis laxa autosomal recessive type 2A (ARCL2A) [MIM:219200]. An autosomal recessive disorder characterized by an excessive congenital skin wrinkling, a large fontanelle with delayed closure, a typical facial appearance with downslanting palpebral fissures, a general connective tissue weakness, and varying degrees of growth and developmental delay and neurological abnormalities. Some affected individuals develop seizures and mental deterioration later in life, whereas the skin phenotype tends to become milder with age. At the molecular level, an abnormal glycosylation of serum proteins is observed in many cases.
    Defects in ATP6V0A2 are a cause of wrinkly skin syndrome (WSS) [MIM:278250]. WSS is rare autosomal recessive disorder characterized by wrinkling of the skin of the dorsum of the hands and feet, an increased number of palmar and plantar creases, wrinkled abdominal skin, multiple musculoskeletal abnormalities, microcephaly, growth failure and developmental delay.
  • 序列相似性Belongs to the V-ATPase 116 kDa subunit family.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cell membrane. Endosome membrane. In kidney proximal tubules, also detected in subapical vesicles.
  • Information by UniProt
  • 数据库链接
  • 别名
    • a2 antibody
    • A2V ATPase antibody
    • ARCL antibody
    • ATP6a2 antibody
    • ATP6N1D antibody
    • ATP6V0A2 antibody
    • ATPase, H+ transporting, lysosomal V0 subunit a isoform 2 antibody
    • ATPase, H+ transporting, lysosomal V0 subunit a2 antibody
    • Infantile malignant osteopetrosis antibody
    • J6B7 antibody
    • Lysosomal H(+) transporting ATPase V0 subunit a2 antibody
    • Lysosomal H(+)-transporting ATPase V0 subunit a2 antibody
    • regeneration and tolerance factor antibody
    • Stv1 antibody
    • TJ6 antibody
    • TJ6M antibody
    • TJ6s antibody
    • V ATPase 116 kDa isoform a2 antibody
    • V type proton ATPase 116 kDa subunit a antibody
    • V type proton ATPase 116 kDa subunit a isoform 2 antibody
    • V-ATPase 116 kDa isoform a2 antibody
    • V-type proton ATPase 116 kDa subunit a isoform 2 antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a antibody
    • Vacuolar proton translocating ATPase 116 kDa subunit a isoform 2 antibody
    • Vph1 antibody
    • VPP2_HUMAN antibody
    • WSS antibody
    see all

Anti-ATP6V0A2 antibody 图像

  • All lanes : Anti-ATP6V0A2 antibody (ab96803) at 1/10000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : A431 whole cell lysate
    Lane 3 : H1299 whole cell lysate

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 98 kDa
  • ab96803, at 1/500 dilution, staining ATP6V0A2 in paraffin-embedded DLD1 xenograft by Immunohistochemistry.

Anti-ATP6V0A2 antibody (ab96803)参考文献

ab96803 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab96803.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"