Anti-ATP-binding cassette sub-family A member 3抗体(ab99856)
Key features and details
- Rabbit polyclonal to ATP-binding cassette sub-family A member 3
- Suitable for: WB, ICC/IF
- Reacts with: Human
- Isotype: IgG
概述
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产品名称
Anti-ATP-binding cassette sub-family A member 3抗体
参阅全部 ATP-binding cassette sub-family A member 3 一抗 -
描述
兔多克隆抗体to ATP-binding cassette sub-family A member 3 -
宿主
Rabbit -
经测试应用
适用于: WB, ICC/IFmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Recombinant fragment corresponding to Human ATP-binding cassette sub-family A member 3 aa 1 to the C-terminus. BC062779.1
Database link: Q99758-2 -
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
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形式
Liquid -
存放说明
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C. Avoid freeze / thaw cycle. -
存储溶液
pH: 7.20
Preservative: 0.02% Sodium azide
Constituent: PBS -
Concentration information loading...
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纯度
Protein A purified -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
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Compatible Secondaries
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Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab99856于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
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WB |
1/1000 - 1/2000. Predicted molecular weight: 191 kDa.
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ICC/IF | (1) |
Use at an assay dependent concentration.
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说明 |
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WB
1/1000 - 1/2000. Predicted molecular weight: 191 kDa. |
ICC/IF
Use at an assay dependent concentration. |
靶标
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功能
Plays an important role in the formation of pulmonary surfactant, probably by transporting lipids such as cholesterol. -
组织特异性
Highly expressed in lung, followed by brain, pancreas, skeletal muscle and heart. Weakly expressed in placenta, kidney and liver. Also expressed in medullary thyroid carcinoma cells (MTC) and in C-cell carcinoma. -
疾病相关
Defects in ABCA3 are the cause of pulmonary surfactant metabolism dysfunction type 3 (SMDP3) [MIM:610921]; also called pulmonary alveolar proteinosis due to ABCA3 deficiency. A rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress. -
序列相似性
Belongs to the ABC transporter superfamily. ABCA family.
Contains 2 ABC transporter domains. -
结构域
Multifunctional polypeptide with two homologous halves, each containing an hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain. -
细胞定位
Membrane. - Information by UniProt
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数据库链接
- Entrez Gene: 21 Human
- Entrez Gene: 27410 Mouse
- Entrez Gene: 302973 Rat
- Omim: 601615 Human
- SwissProt: Q99758 Human
- SwissProt: Q8R420 Mouse
- SwissProt: P16970 Rat
- Unigene: 26630 Human
see all -
别名
- ABC 3 antibody
- ABC C antibody
- ABC C transporter antibody
see all
图片
数据表及文件
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Datasheet download
文献 (2)
ab99856 被引用在 2 文献中.
- Kathiriya JJ et al. Human alveolar type 2 epithelium transdifferentiates into metaplastic KRT5+ basal cells. Nat Cell Biol 24:10-23 (2022). PubMed: 34969962
- Sengupta A et al. A New Immortalized Human Alveolar Epithelial Cell Model to Study Lung Injury and Toxicity on a Breathing Lung-On-Chip System. Front Toxicol 4:840606 (2022). PubMed: 35832493