概述

  • 产品名称Anti-ATG16L1抗体
    参阅全部 ATG16L1 一抗
  • 描述
    兔多克隆抗体to ATG16L1
  • 经测试应用适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to 18 amino acids from near the center of human ATG16L1 (NP_110430).

  • 阳性对照
    • HeLa cells

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应用

Our Abpromise guarantee covers the use of ab106354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 0.25 - 0.5 µg/ml. Predicted molecular weight: 68 kDa.
ICC Use a concentration of 2 µg/ml.

靶标

  • 功能Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane.
  • 疾病相关Inflammatory bowel disease 10
  • 序列相似性Belongs to the WD repeat ATG16 family.
    Contains 7 WD repeats.
  • 翻译后修饰Proteolytic cleavage by activated CASP3 leads to degradation and may regulate autophagy upon cellular stress and apoptotic stimuli.
  • 细胞定位Cytoplasm. Preautophagosomal structure membrane. Recruited to omegasomes membranes by WIPI2. Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.
  • Information by UniProt
  • 数据库链接
  • 形式There are 4 isoforms produced by alternative splicing.
  • 别名
    • A16L1_HUMAN antibody
    • APG16 like 1 antibody
    • APG16-like 1 antibody
    • APG16L antibody
    • APG16L beta antibody
    • ATG16 autophagy related 16 like 1 antibody
    • ATG16 autophagy related 16-like 1 (S. cerevisiae) antibody
    • ATG16A antibody
    • ATG16L antibody
    • Atg16l1 antibody
    • Autophagy related protein 16 1 antibody
    • Autophagy-related protein 16-1 antibody
    • FLJ00045 antibody
    • FLJ10035 antibody
    • FLJ10828 antibody
    • FLJ22677 antibody
    • IBD10 antibody
    • OTTHUMP00000164391 antibody
    • OTTHUMP00000164393 antibody
    • OTTHUMP00000165876 antibody
    • OTTHUMP00000165877 antibody
    • WD repeat domain 30 antibody
    • WDR30 antibody
    see all

Anti-ATG16L1 antibody 图像

  • Lane 1 : Anti-ATG16L1 antibody (ab106354) at 0.25 µg/ml
    Lane 2 : Anti-ATG16L1 antibody (ab106354) at 0.5 µg/ml

    Lane 1 : HeLa Cell lysate
    Lane 2 : HeLa Cell lysate

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 68 kDa
  • Immunocytochemistry of ATG16 in HeLa cells with ATG16 antibody (ab106354) at 2 µg/ml.
  • Immunofluorescence of ATG16 in Hela cells using ab106354 at 4 ug/ml.

Anti-ATG16L1 antibody (ab106354)参考文献

ab106354 has not yet been referenced specifically in any publications.

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