概述

  • 产品名称
  • 描述
    小鼠多克隆抗体to ATF7
  • 经测试应用
    适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length Human ATF7 (NP_006847.1, amino acids 1-483)

  • 阳性对照
    • HeLa nuclear extract and ATF7 transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab89523 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 53 kDa.

靶标

  • 功能
    Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.
    Isoform 4/ATF-A0 acts as a dominant repressor of the E-selectin/NF-ELAM1/delta-A promoter.
  • 组织特异性
    Expressed in heart, lung and skeletal muscle. Isoform 4 is expressed in various tissues including heart, brain, placenta, lung and skeletal muscle. Highest levels in skeletal muscle. Lowest in lung and placenta.
  • 序列相似性
    Belongs to the bZIP family.
    Contains 1 bZIP domain.
    Contains 1 C2H2-type zinc finger.
  • 翻译后修饰
    On EGF stimulation, phosphorylated first on Thr-53 allowing subsequent phosphorylation on Thr-51. This latter phosphorylation prevents sumoylation, increases binding to TAF12 and enhances transcriptional activity.
    Sumoylation delays nuclear localization and inhibits transactivation activity through preventing binding to TAF12. RANBP2 appears to be the specific E3 ligase.
  • 细胞定位
    Nucleus. Nucleus > nucleoplasm. Mainly nucleoplasmic. Restricted distribution to the perinuculear region. The sumoylated form locates to the nuclear periphery.
  • Information by UniProt
  • 数据库链接
  • 别名
    • 1110012F10Rik antibody
    • 9430065F09Rik antibody
    • Activating transcription factor 7 antibody
    • AI549878 antibody
    • ATF7 antibody
    • Atf7 protein antibody
    • ATF7_HUMAN antibody
    • ATFA antibody
    • C130020M04Rik antibody
    • cAMP-dependent transcription factor ATF-7 antibody
    • Cyclic AMP-dependent transcription factor ATF 7 antibody
    • Cyclic AMP-dependent transcription factor ATF-7 antibody
    • MGC31554 antibody
    • MGC57182 antibody
    • Transcription factor ATF A antibody
    • Transcription factor ATF-A antibody
    see all

图片

实验方案

文献

ab89523 has not yet been referenced specifically in any publications.

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