概述

  • 产品名称Anti-ATF6 beta抗体
    参阅全部 ATF6 beta 一抗
  • 描述
    兔多克隆抗体to ATF6 beta
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide derived from an internal region of Human ATF6 beta

  • 阳性对照
    • extracts from COLO205 cells

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液Preservative: 0.02% Sodium Azide
    Constituents: 50% Glycerol, PBS (without Mg2+ and Ca2+), 150mM Sodium chloride, pH 7.4
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab72600 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/1000. Detects a band of approximately 77 kDa (predicted molecular weight: 77 kDa).
ELISA 1/20000.

靶标

  • 功能Transcriptional factor that acts in the unfolded protein response (UPR) pathway by activating UPR target genes induced during ER stress. Binds DNA on the 5'-CCAC[GA]-3' half of the ER stress response element (ERSE) (5'-CCAATN(9)CCAC[GA]-3') when NF-Y is bound to ERSE.
  • 组织特异性Ubiquitous.
  • 序列相似性Belongs to the bZIP family. ATF subfamily.
    Contains 1 bZIP domain.
  • 结构域The basic domain functions as a nuclear localization signal.
    The basic leucine-zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE.
  • 翻译后修饰N-glycosylated.
    During unfolded protein response an approximative 60 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage is probably performed sequentially by site-1 and site-2 proteases.
  • 细胞定位Endoplasmic reticulum membrane and Nucleus. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Activating transcription factor 6 beta antibody
    • ATF 6 beta antibody
    • ATF6-beta antibody
    • ATF6B antibody
    • ATF6B_HUMAN antibody
    • ATF6beta antibody
    • cAMP response element binding protein related protein antibody
    • cAMP response element-binding protein-related protein antibody
    • cAMP responsive element binding protein like 1 antibody
    • cAMP-dependent transcription factor ATF-6 beta antibody
    • cAMP-responsive element-binding protein-like 1 antibody
    • CREB L1 antibody
    • Creb related protein antibody
    • CREB RP antibody
    • Creb-rp antibody
    • CREBL 1 antibody
    • CREBL1 antibody
    • Crebrp antibody
    • Cyclic AMP dependent transcription factor ATF 6 beta antibody
    • Cyclic AMP dependent transcription factor ATF6 beta antibody
    • FLJ10066 antibody
    • G13 antibody
    • G13 protein antibody
    • OTTHUMP00000029432 antibody
    • OTTHUMP00000029433 antibody
    • Processed cyclic AMP-dependent transcription factor ATF-6 beta antibody
    • Protein G13 antibody
    see all

Anti-ATF6 beta antibody 图像

  • All lanes : Anti-ATF6 beta antibody (ab72600) at 1/500 dilution

    Lane 1 : extracts from COLO205 cells
    Lane 2 : extracts from COLO205 cells, with 10ug immunising peptide

    Lysates/proteins at 30 µg per lane.


    Predicted band size : 77 kDa
    Observed band size : 76 kDa (why is the actual band size different from the predicted?)
    Additional bands at : 26 kDa. We are unsure as to the identity of these extra bands.

Anti-ATF6 beta antibody (ab72600)参考文献

ab72600 has not yet been referenced specifically in any publications.

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