概述

  • 产品名称Anti-ATF1抗体
    参阅全部 ATF1 一抗
  • 描述
    兔多克隆抗体to ATF1
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Dog, Xenopus laevis, Chimpanzee, Rhesus monkey, Xenopus tropicalis , Platypus (Ornithorhynchus anatinus)
  • 免疫原

    Synthetic peptide corresponding a region between residues 171 and 221 of Human ATF1 (NP_005162.1).

  • 阳性对照
    • HeLa whole cell lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • 存储溶液pH: 7.00
    Preservative: 0.09% Sodium azide
    Constituent: Tris citrate/phosphate
    Note: pH 7 to 8
  • Concentration information loading...
  • 纯度Immunogen affinity purified
  • 纯化说明ab110869 was affinity purified using an epitope specific to ATF1 immobilized on solid support.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab110869 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 2-5 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes.
    • 疾病相关Defects in ATF1 may be a cause of angiomatoid fibrous histiocytoma (AFH) [MIM:612160]. A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis. Note=Chromosomal aberrations involving ATF1 are found in patients with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with FUS generates a chimeric ATF1/FUS protein. Translocation t(12;22)(q13;q12) with EWSR1 generates a chimeric ATF1/EWSR1 protein.
    • 序列相似性Belongs to the bZIP family. ATF subfamily.
      Contains 1 bZIP domain.
      Contains 1 KID (kinase-inducible) domain.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • Activating transcription factor 1 antibody
      • ATF 1 antibody
      • atf1 antibody
      • ATF1 EWS fusion gene antibody
      • ATF1 FUS fusion gene antibody
      • ATF1_HUMAN antibody
      • cAMP dependent transcription factor 1 antibody
      • cAMP-dependent transcription factor ATF-1 antibody
      • Cyclic AMP dependent transcription factor ATF 1 antibody
      • Cyclic AMP dependent transcription factor ATF1 antibody
      • Cyclic AMP-dependent transcription factor ATF-1 antibody
      • EWS AFT1 antibody
      • FUS ATF 1 antibody
      • FUS/ATF 1 antibody
      • Protein TREB36 antibody
      • RNA binding protein activating transcription factor 1 fusion protein antibody
      • TREB 36 antibody
      • TREB36 antibody
      • TREB36 protein antibody
      see all

    Anti-ATF1 antibody 图像

    • Detection of ATF1 by Western Blot of Immunprecipitate.
      anti-ATF1 at 0.4µg/ml staining ATF1 in HeLa whole cell lysate immunoprecipitated using ab110869 at 6µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
      Detection: Chemiluminescence with exposure time of 10 seconds.

    Anti-ATF1 antibody (ab110869)参考文献

    ab110869 has not yet been referenced specifically in any publications.

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