概述

  • 产品名称Anti-Ataxin 1抗体
    参阅全部 Ataxin 1 一抗
  • 描述
    兔多克隆抗体to Ataxin 1
  • 经测试应用适用于: IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Human
    预测可用于: Chimpanzee, Rhesus monkey, Gorilla
  • 免疫原

    Synthetic peptide, corresponding to a region between amino acids 350-400 of Human Ataxin 1 (NP_000323.2).

  • 阳性对照
    • HeLa whole cell lysate

性能

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应用

Our Abpromise guarantee covers the use of ab114045 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IP Use at 10 µg/mg of lysate.
  • 应用说明Is unsuitable for WB.
  • 靶标

    • 功能Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
    • 组织特异性Widely expressed throughout the body.
    • 疾病相关Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400]; also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
    • 序列相似性Belongs to the ATXN1 family.
      Contains 1 AXH domain.
    • 结构域The AXH domain is required for interaction with CIC.
    • 翻译后修饰Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract.
      Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
    • 细胞定位Cytoplasm. Nucleus. Colocalizes with USP7 in the nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • alternative ataxin1 antibody
      • Ataxin-1 antibody
      • ATX1 antibody
      • ATX1_HUMAN antibody
      • Atxn1 antibody
      • D6S504E antibody
      • OTTHUMP00000016065 antibody
      • SCA1 antibody
      • Spinocerebellar ataxia type 1 protein antibody
      see all

    Anti-Ataxin 1 antibody 图像

    • Detection of Ataxin 1 in Immunoprecipitates of HeLa whole cell lysate (1 mg for IP, 20% of IP loaded) using ab114045 at 10 µg/mg lysate for IP. An anti-Ataxin 1 antibody which recognizes a downstream epitope was used at 1 µg/ml for subsequent western blot detection. Detection: Chemiluminescence with exposure time of 3 seconds.

      Predicted band size : 87 kDa.

    Anti-Ataxin 1 antibody (ab114045)参考文献

    ab114045 has not yet been referenced specifically in any publications.

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