概述

  • 产品名称Anti-Ataxin 1抗体
    参阅全部 Ataxin 1 一抗
  • 描述
    兔多克隆抗体to Ataxin 1
  • 经测试应用适用于: IHC-P, ICC/IFmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide, corresponding to amino acids 741-791 of Human Ataxin 1

  • 阳性对照
    • NIH3T3 cells and Human lung carcinoma tissue.

性能

应用

Our Abpromise guarantee covers the use of ab110833 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/500.

靶标

  • 功能Binds RNA in vitro. May be involved in RNA metabolism. The expansion of the polyglutamine tract may alter this function.
  • 组织特异性Widely expressed throughout the body.
  • 疾病相关Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400]; also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.
  • 序列相似性Belongs to the ATXN1 family.
    Contains 1 AXH domain.
  • 结构域The AXH domain is required for interaction with CIC.
  • 翻译后修饰Phosphorylation at Ser-775 increases the pathogenicity of proteins with an expanded polyglutamine tract.
    Sumoylation is dependent on nuclear localization and phosphorylation at Ser-775. It is reduced in the presence of an expanded polyglutamine tract.
  • 细胞定位Cytoplasm. Nucleus. Colocalizes with USP7 in the nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • alternative ataxin1 antibody
    • Ataxin-1 antibody
    • ATX1 antibody
    • ATX1_HUMAN antibody
    • Atxn1 antibody
    • D6S504E antibody
    • OTTHUMP00000016065 antibody
    • SCA1 antibody
    • Spinocerebellar ataxia type 1 protein antibody
    see all

Anti-Ataxin 1 antibody 图像

  • ab110833 at 1/50 staining Ataxin 1 in paraffin-embedded Human lung carcinoma tissue, left panel shows staining without immunizing peptide right panel shows staining with immunizing peptide.
  • ab110833 at 1/100 staining Ataxin in NIH3T3 cells by immunofluorescence, left panel shows staining without immunizing peptide right panel shows staining with immunizing peptide.

Anti-Ataxin 1 antibody (ab110833)参考文献

ab110833 has not yet been referenced specifically in any publications.

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