The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 159 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
功能May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells.
组织特异性Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors.
序列相似性Belongs to the AAA ATPase family. Contains 1 bromo domain.