概述

  • 产品名称
  • 描述
    兔多克隆抗体to AT11A
  • 经测试应用
    适用于: ELISA, ICC, WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region within N terminal of Human AT11A.

  • 阳性对照
    • Human testis tissue.

性能

应用

Our Abpromise guarantee covers the use of ab117577 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA Use at an assay dependent concentration.
ICC Use at an assay dependent concentration.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 129 kDa.
IHC-P Use a concentration of 5 µg/ml.

靶标

  • 功能
    Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
  • 序列相似性
    Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
  • 细胞定位
    Cell membrane. Early endosome. Recycling endosome. Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 形式
    P-type ATPases, such as ATP11A, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes.
  • 别名
    • AT11A_HUMAN antibody
    • Atp11a antibody
    • ATPase class VI type 11A antibody
    • ATPase IS antibody
    • ATPIH antibody
    • ATPIS antibody
    • P4-ATPase flippase complex alpha subunit ATP11A antibody
    • Probable phospholipid-transporting ATPase IH antibody
    see all

Anti-AT11A antibody 图像

  • Immunohistochemical analysis of AT11A expression in Formalin-Fixed, Paraffin-Embedded Human Testis using 5 µg/ml ab117577.

Anti-AT11A antibody (ab117577)参考文献

ab117577 has not yet been referenced specifically in any publications.

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