Anti-AT11A抗体(ab105351)

概述

  • 产品名称Anti-AT11A抗体
    参阅全部 AT11A 一抗
  • 描述
    兔多克隆抗体to AT11A
  • 特异性ab105351 is predicted to not cross react with AT11B. At least two isoforms of AT11A are known to exist; this antibody will recognize both.
  • 经测试应用适用于: ICC/IF, WB, ICCmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    A 19 amino acid peptide from a region within the N terminus of Human AT11A (NP_115565).

  • 阳性对照
    • WB: K562 cell lysate ICC: K562 cells

性能

相关产品

应用

Our Abpromise guarantee covers the use of ab105351 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ICC/IF Use a concentration of 20 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Predicted molecular weight: 130 kDa.
ICC Use a concentration of 10 µg/ml.

靶标

  • 功能Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules (Probable). May be involved in the uptake of farnesyltransferase inhibitor drugs, such as lonafarnib.
  • 序列相似性Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.
  • 细胞定位Cell membrane. Early endosome. Recycling endosome. Endoplasmic reticulum. Exit from the endoplasmic reticulum requires the presence of TMEM30A, but not TMEM30B. In the presence of TMEM30A, predominantly located in the plasma membrane.
  • Information by UniProt
  • 数据库链接
  • 形式P-type ATPases, such as ATP11A, are phosphorylated in their intermediate state and drive uphill transport of ions across membranes.
  • 别名
    • AT11A_HUMAN antibody
    • Atp11a antibody
    • ATPase class VI type 11A antibody
    • ATPase IS antibody
    • ATPIH antibody
    • ATPIS antibody
    • P4-ATPase flippase complex alpha subunit ATP11A antibody
    • Probable phospholipid-transporting ATPase IH antibody
    see all

Anti-AT11A antibody 图像

  • Immunofluorescence of ATP11A in K562 cells with ab105351 at 20 ug/mL.

  • All lanes : Anti-AT11A antibody (ab105351) at 1 µg/ml

    Lane 1 : K562 cell lysate
    Lane 2 : K562 cell lysate with blocking peptide

    Lysates/proteins at 15 µg per lane.


    Predicted band size : 130 kDa
  • ab105351, at 10 µg/ml, staining AT11A in K562 cells by Immunocytochemistry.

Anti-AT11A antibody (ab105351)参考文献

ab105351 has not yet been referenced specifically in any publications.

Product Wall

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"