The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
应用说明WB: 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: Isoform 2, 98 kDa; Isoform 1, 154 kDa).
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
功能Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.
疾病相关Note=A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with MYST3 generates a MYST3-ASXL2 fusion protein.
序列相似性Belongs to the Asx family. Contains 1 PHD-type zinc finger.
结构域Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.
翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.