概述

  • 产品名称Anti-ASXL2抗体
    参阅全部 ASXL2 一抗
  • 描述
    小鼠多克隆抗体to ASXL2
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Full length human ASXL2 protein (AAH42999, 1 a.a. ~ 918 a.a)

  • 阳性对照
    • ASXL2 transfected 293T cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab69420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: 1/500 - 1/1000. Detects a band of approximately 95 kDa (predicted molecular weight: Isoform 2, 98 kDa; Isoform 1, 154 kDa).


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Putative Polycomb group (PcG) protein. PcG proteins act by forming multiprotein complexes, which are required to maintain the transcriptionally repressive state of homeotic genes throughout development. PcG proteins are not required to initiate repression, but to maintain it during later stages of development. They probably act via methylation of histones, rendering chromatin heritably changed in its expressibility.
    • 疾病相关Note=A chromosomal aberration involving ASXL2 is a cause of therapy-related myelodysplastic syndrome. Translocation t(2;8)(p23;p11.2) with MYST3 generates a MYST3-ASXL2 fusion protein.
    • 序列相似性Belongs to the Asx family.
      Contains 1 PHD-type zinc finger.
    • 结构域Contains two Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs, which may be required for an association with nuclear receptors.
    • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
    • 细胞定位Nucleus.
    • Information by UniProt
    • 数据库链接
    • 形式There are 2 isoforms produced by alternative splicing.
    • 别名
      • additional sex combs like 2 (Drosophila) antibody
      • Additional sex combs like 2 antibody
      • Additional sex combs like protein 2 antibody
      • Additional sex combs-like protein 2 antibody
      • ASXH2 antibody
      • ASXL 2 antibody
      • ASXL2 antibody
      • ASXL2_HUMAN antibody
      • DKFZp686C1968 antibody
      • FLJ10898 antibody
      • KIAA1685 antibody
      • Polycomb group protein ASXH2 antibody
      • Putative Polycomb group protein ASXL2 antibody
      see all

    Anti-ASXL2 antibody 图像

    • All lanes : Anti-ASXL2 antibody (ab69420) at 1/500 dilution

      Lane 1 : ASXL2 transfected 293T cell lysate
      Lane 2 : Non-transfected 293T cell lysate

      Lysates/proteins at 25 µg per lane.

      Secondary
      Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

      Predicted band size : 98 kDa
      Observed band size : 95 kDa (why is the actual band size different from the predicted?)
      Additional bands at : 150 kDa. We are unsure as to the identity of these extra bands.

    Anti-ASXL2 antibody (ab69420)参考文献

    ab69420 has not yet been referenced specifically in any publications.

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