概述

  • 产品名称Anti-ASS1抗体
    参阅全部 ASS1 一抗
  • 描述
    兔多克隆抗体to ASS1
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within the amino acids 23-168 of Human ASS1 (NP_446464).

  • 阳性对照
    • WB: A431, HepG2 cell lysates IHC-P: Cal27 tissue

性能

应用

Our Abpromise guarantee covers the use of ab96433 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 47 kDa.
IHC-P 1/100 - 1/500. Antigen retrieval is not essential but may optimise staining.

靶标

  • 通路Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
    Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.
  • 疾病相关Defects in ASS1 are the cause of citrullinemia type 1 (CTLN1) [MIM:215700]. Citrullinemia belongs to the urea cycle disorders. It is an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. CTLN1 usually manifests in the first few days of life. Affected infants appear normal at birth, but as ammonia builds up in the body they present symptoms such as lethargy, poor feeding, vomiting, seizures and loss of consciousness. Less commonly, a milder CTLN1 form can develop later in childhood or adulthood.
  • 序列相似性Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Argininosuccinate synthase 1 antibody
    • Argininosuccinate synthase antibody
    • Argininosuccinate synthetase 1 antibody
    • ASS antibody
    • Ass-1 antibody
    • ass1 antibody
    • ASSA antibody
    • ASSY_HUMAN antibody
    • Citrulline aspartate ligase antibody
    • Citrulline--aspartate ligase antibody
    • CTLN1 antibody
    see all

Anti-ASS1 antibody 图像

  • Anti-ASS1 antibody (ab96433) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size : 47 kDa
  • Immunohistochemical analysis of ASS1 in paraffin embedded Cal27, using ab96433 at a 1/100 dilution.

Anti-ASS1 antibody (ab96433)参考文献

ab96433 has not yet been referenced specifically in any publications.

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