概述

  • 产品名称Anti-ASS1抗体
    参阅全部 ASS1 一抗
  • 描述
    山羊多克隆抗体to ASS1
  • 经测试应用适用于: WB, IP, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Dog, Pig
  • 免疫原

    Synthetic peptide:

    C-ENPKNQAPPGLYTKTQD

    , corresponding to internal sequence amino acids 196-212 of Human ASS1 (P00966).

  • 阳性对照
    • Human kidney and liver tissue; Human kidney lysate

性能

应用

Our Abpromise guarantee covers the use of ab109753 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.01 - 0.03 µg/ml. Predicted molecular weight: 47 kDa.
IP Use at an assay dependent dilution.
ELISA 1/64000.
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 通路Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3.
    Nitrogen metabolism; urea cycle; (N(omega)-L-arginino)succinate from L-aspartate and L-citrulline: step 1/1.
  • 疾病相关Defects in ASS1 are the cause of citrullinemia type 1 (CTLN1) [MIM:215700]. Citrullinemia belongs to the urea cycle disorders. It is an autosomal recessive disease characterized primarily by elevated serum and urine citrulline levels. Ammonia intoxication is another manifestation. CTLN1 usually manifests in the first few days of life. Affected infants appear normal at birth, but as ammonia builds up in the body they present symptoms such as lethargy, poor feeding, vomiting, seizures and loss of consciousness. Less commonly, a milder CTLN1 form can develop later in childhood or adulthood.
  • 序列相似性Belongs to the argininosuccinate synthase family. Type 1 subfamily.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Argininosuccinate synthase 1 antibody
    • Argininosuccinate synthase antibody
    • Argininosuccinate synthetase 1 antibody
    • ASS antibody
    • Ass-1 antibody
    • ass1 antibody
    • ASSA antibody
    • ASSY_HUMAN antibody
    • Citrulline aspartate ligase antibody
    • Citrulline--aspartate ligase antibody
    • CTLN1 antibody
    see all

Anti-ASS1 antibody 图像

  • ab109753, at 2.5 µg/ml, staining ASS1 in formalin fixed, paraffin embedded Human kidney tissue by Immunohistochemistry.
  • ab109753, at 2.5 µg/ml, staining ASS1 in formalin fixed, paraffin embedded Human liver tissue by Immunohistochemistry.
  • Anti-ASS1 antibody (ab109753) at 0.03 µg/ml + Human kidney lysate (in RIPA buffer) at 35 µg

    Predicted band size : 47 kDa

Anti-ASS1 antibody (ab109753)参考文献

ab109753 has not yet been referenced specifically in any publications.

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