概述

  • 产品名称Anti-ASPA抗体
    参阅全部 ASPA 一抗
  • 描述
    小鼠单克隆抗体to ASPA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Recombinant Fragment
    预测可用于: Human
  • 免疫原

    Recombinant fragment: MTSCHIAEEH IQKVAIFGGT HGNELTGVFL VKHWLENGAE IQRTGLEVKP FITNPRAVKK CTRYIDCDLN RIFDLENLGK KMSEDLPYEV RRAQEINHLF , corresponding to amino acids 1-101 of Human ASPA

性能

应用

Our Abpromise guarantee covers the use of ab54849 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
    • 组织特异性Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
    • 疾病相关Defects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average.
    • 序列相似性Belongs to the AspA/AstE family. Aspartoacylase subfamily.
    • 细胞定位Cytoplasm. Nucleus.
    • Information by UniProt
    • 数据库链接
    • 别名
      • ACY 2 antibody
      • ACY-2 antibody
      • ACY2 antibody
      • ACY2_HUMAN antibody
      • Aminoacylase 2 antibody
      • Aminoacylase-2 antibody
      • Aminoacylase2 antibody
      • ASP antibody
      • ASPA antibody
      • Aspartoacylase (aminoacylase 2, Canavan disease) antibody
      • Aspartoacylase (Canavan disease) antibody
      • Aspartoacylase antibody
      • NUR 7 antibody
      • NUR7 antibody
      • OTTMUSP00000006437 antibody
      • RP23-213I10.1 antibody
      • Small lethargic antibody
      see all

    Anti-ASPA antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab54849 ASPA antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa.

      This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Anti-ASPA antibody (ab54849)参考文献

    ab54849 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"