概述

  • 产品名称Anti-ASPA抗体
    参阅全部 ASPA 一抗
  • 描述
    山羊多克隆抗体to ASPA
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Mouse, Rat
  • 免疫原

    Synthetic peptide:

    TLSAKSIRSTLH

    by a Cysteine residue linker, corresponding to C terminal amino acids 301-312 of Mouse ASPA (NP_075602.2).

  • 阳性对照
    • Mouse and Rat kidney lysates.

性能

应用

Our Abpromise guarantee covers the use of ab112530 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 35 kDa (predicted molecular weight: 35 kDa). For 1 hour.

靶标

  • 功能Catalyzes the deacetylation of N-acetylaspartic acid (NAA) to produce acetate and L-aspartate. NAA occurs in high concentration in brain and its hydrolysis NAA plays a significant part in the maintenance of intact white matter. In other tissues it act as a scavenger of NAA from body fluids.
  • 组织特异性Brain white matter, skeletal muscle, kidney, adrenal glands, lung and liver.
  • 疾病相关Defects in ASPA are the cause of Canavan disease (CAND) [MIM:271900]; also known as spongy degeneration of the brain. CAND is a rare neurodegenerative condition of infancy or childhood characterized by white matter vacuolization and demeylination that gives rise to a spongy appearance. The clinical features are onset in early infancy, atonia of neck muscles, hypotonia, hyperextension of legs and flexion of arms, blindness, severe mental defect, megalocephaly, and death by 18 months on the average.
  • 序列相似性Belongs to the AspA/AstE family. Aspartoacylase subfamily.
  • 细胞定位Cytoplasm. Nucleus.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ACY 2 antibody
    • ACY-2 antibody
    • ACY2 antibody
    • ACY2_HUMAN antibody
    • Aminoacylase 2 antibody
    • Aminoacylase-2 antibody
    • Aminoacylase2 antibody
    • ASP antibody
    • ASPA antibody
    • Aspartoacylase (aminoacylase 2, Canavan disease) antibody
    • Aspartoacylase (Canavan disease) antibody
    • Aspartoacylase antibody
    • NUR 7 antibody
    • NUR7 antibody
    • OTTMUSP00000006437 antibody
    • RP23-213I10.1 antibody
    • Small lethargic antibody
    see all

Anti-ASPA antibody 图像

  • Anti-ASPA antibody (ab112530) at 0.01 µg/ml + Mouse Kidney lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 35 kDa

Anti-ASPA antibody (ab112530)参考文献

ab112530 has not yet been referenced specifically in any publications.

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