概述

  • 产品名称Anti-ARTS1抗体[EPR6069]
    参阅全部 ARTS1 一抗
  • 描述
    兔单克隆抗体[EPR6069] to ARTS1
  • 经测试应用适用于: WB, IHC-P, ICCmore details
    不适用于: Flow Cyt or IP
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide corresponding to C-terminal amino acids of Human ARTS1.

  • 阳性对照
    • K562, HUVEC and A431 cell lysates; Human uterus tissue.
  • 常规说明

    This product is a recombinant rabbit monoclonal antibody.

    Produced using Abcam’s RabMAb® technology. RabMAb® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

性能

应用

Our Abpromise guarantee covers the use of ab124669 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000 - 1/10000. Predicted molecular weight: 107 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol.
ICC 1/250 - 1/500.
  • 应用说明Is unsuitable for Flow Cyt or IP.
  • 靶标

    • 功能Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
    • 组织特异性Ubiquitous.
    • 序列相似性Belongs to the peptidase M1 family.
    • 翻译后修饰N-glycosylated.
    • 细胞定位Endoplasmic reticulum membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • A LAP antibody
      • A-LAP antibody
      • Adipocyte derived leucine aminopeptidase antibody
      • Adipocyte-derived leucine aminopeptidase antibody
      • ALAP antibody
      • Aminopeptidase PILS antibody
      • Aminopeptidase regulator of TNFR1 shedding antibody
      • APPILS antibody
      • ARTS 1 antibody
      • ARTS-1 antibody
      • Arts1 antibody
      • Endoplasmic reticulum aminopeptidase 1 antibody
      • Endoplasmic reticulum aminopeptidase associated with antigen processing antibody
      • ERAAP antibody
      • ERAAP1 antibody
      • ERAP 1 antibody
      • Erap1 antibody
      • ERAP1_HUMAN antibody
      • KIAA0525 antibody
      • kiaa0525 protein antibody
      • PILS AP antibody
      • PILS-AP antibody
      • PILSA antibody
      • PILSAP antibody
      • Puromycin insensitive leucyl specific aminopeptidase antibody
      • Puromycin-insensitive leucyl-specific aminopeptidase antibody
      • Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator antibody
      • type 1 tumor necrosis factor receptors shedding aminopeptidase regulator antibody
      • VEGF-induced aminopeptidase antibody
      see all

    Anti-ARTS1 antibody [EPR6069] 图像

    • All lanes : Anti-ARTS1 antibody [EPR6069] (ab124669) at 1/1000 dilution

      Lane 1 : K562 cell lysate
      Lane 2 : HUVEC cell lysate
      Lane 3 : A431 cell lysate

      Lysates/proteins at 10 µg per lane.

      Secondary
      Goat anti-rabbit HRP at 2000

      Predicted band size : 107 kDa
    • ab124669, at a 1/50 dilution, staining ARTS1 in paraffin embedded Human uterus tissue by Immunohistochemistry.

    Anti-ARTS1 antibody [EPR6069] (ab124669)参考文献

    This product has been referenced in:
    • Wang B  et al. p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1. Nat Commun 4:2359 (2013). WB . Read more (PubMed: 23965983) »

    See 1 Publication for this product

    Product Wall

    There are currently no Abreviews or Questions for ab124669.
    Please use the links above to contact us or submit feedback about this product.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"