概述

  • 产品名称Anti-Arp2抗体[FMS96]
    参阅全部 Arp2 一抗
  • 描述
    小鼠单克隆抗体[FMS96] to Arp2
  • 特异性This antibody recognizes Arp2 (approx. 40-45 kDa).
  • 经测试应用适用于: Indirect ELISA, ICC/IF, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Dog, Human
  • 免疫原

    Recombinant full length protein (Human)

  • 阳性对照
    • Total cell extract of C2 mouse myoblast cells.

性能

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应用

Our Abpromise guarantee covers the use of ab49674 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Indirect ELISA Use at an assay dependent dilution.
ICC/IF Use a concentration of 10 µg/ml.
WB Use a concentration of 0.5 - 1 µg/ml. Detects a band of approximately 40-45 kDa (predicted molecular weight: 45 kDa).

靶标

  • 功能Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament.
  • 序列相似性Belongs to the actin family. ARP2 subfamily.
  • 细胞定位Cytoplasm > cytoskeleton. Cell projection.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Actin like protein 2 antibody
    • Actin related protein 2 antibody
    • Actin-like protein 2 antibody
    • Actin-related protein 2 antibody
    • ACTR2 antibody
    • ARP2 actin related protein 2 homolog (yeast) antibody
    • ARP2 antibody
    • ARP2/3 COMPLEX antibody
    • ARP2_HUMAN antibody
    • OTTHUMP00000159937 antibody
    • OTTHUMP00000202270 antibody
    see all

Anti-Arp2 antibody [FMS96] 图像

  • C2C12 cells were incubated with ab49674 at 10 µg/ml followed by Goat Anti Mouse IgG Alexa-488 (green staining). The red staining is obtained by staining actin with Alexa-546 phalloidin.
  • Immunofluorescence analysis of dendritic cells infected with HIV, staining Arp2 (blue) with ab49674 at 5 mg/ml.

Anti-Arp2 antibody [FMS96] (ab49674)参考文献

This product has been referenced in:
  • Wang F  et al. Arp2/3 complex inhibition prevents meiotic maturation in porcine oocytes. PLoS One 9:e87700 (2014). ICC/IF ; Pig . Read more (PubMed: 24498171) »
  • Naj X  et al. The formins FMNL1 and mDia1 regulate coiling phagocytosis of Borrelia burgdorferi by primary human macrophages. Infect Immun 81:1683-95 (2013). Human . Read more (PubMed: 23460512) »

See all 6 Publications for this product

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