概述

  • 产品名称
  • 描述
    兔多克隆抗体to ARMET
  • 经测试应用
    适用于: WB, ICC/IF, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    12 amino acid peptide from near the amino terminus of human MANF.

性能

  • 形式
    Liquid
  • 存放说明
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液
    Preservative: 0.02% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度
    Purified IgA
  • 克隆
    多克隆
  • 同种型
    IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab67203 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 28 kDa (predicted molecular weight: 20 kDa).
ICC/IF Use a concentration of 20 µg/ml.
IHC-P Use a concentration of 2.5 µg/ml.

靶标

  • 功能
    Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.
  • 序列相似性
    Belongs to the ARMET family.
  • 结构域
    The N-terminal region may be responsible for neurotrophic activity while the C-terminal region may play a role in the ER stress response.
  • 翻译后修饰
    May contain sialic acid residues.
  • 细胞定位
    Secreted.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Arginine rich mutated in early stage tumors antibody
    • Arginine rich protein antibody
    • Arginine-rich protein antibody
    • ARMET antibody
    • ARMET protein antibody
    • ARP antibody
    • Manf antibody
    • MANF_HUMAN antibody
    • Mesencephalic astrocyte derived neurotrophic factor antibody
    • Mesencephalic astrocyte-derived neurotrophic factor antibody
    • MGC142148 antibody
    • MGC142150 antibody
    • Protein ARMET antibody
    see all

图片

  • Lane 1 : Anti-ARMET antibody (ab67203) at 1 µg/ml
    Lane 2 : Anti-ARMET antibody (ab67203) at 2 µg/ml

    Lane 1 : rat brain tissue lysate
    Lane 2 : rat brain tissue lysate


    Predicted band size : 20 kDa
  • Ab67203 (2.5 ug/ml) staining of ARMET in human brain tissue by IHC.
  • Immunofluorescence of MANF in Human Brain cells using ab67203 at 20 ug/ml.

文献

This product has been referenced in:
  • Chen L  et al. Identification of MANF as a protein interacting with RTN1-C. Acta Biochim Biophys Sin (Shanghai) 47:91-7 (2015). Read more (PubMed: 25543119) »
  • Di Penta A  et al. A trifluoromethyl analogue of celecoxib exerts beneficial effects in neuroinflammation. PLoS One 8:e83119 (2013). WB ; Mouse . Read more (PubMed: 24349442) »

See all 2 Publications for this product

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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