This fast track antibody is not yet fully characterized. It is subject to these terms and conditions


  • 产品名称
  • 描述
    山羊多克隆抗体to ARL6

    This product is a fast track antibody. It has been affinity purified and shows high titre values against the immunizing peptide by ELISA. Read the terms of use »

  • 特异性
    Reported variants (NP_816931.1, NP_115522.1) represent identical protein.
  • 种属反应性

    预测可用于: Mouse, Rat, Cow, Dog, Zebrafish
  • 免疫原

    Synthetic peptide:


    with a Cysteine residue linker, corresponding to internal sequence amino acids 38-50 of Mouse ARL6 (NP_062639.3).

  • 常规说明

    Reported variants (NP_816931.1, NP_115522.1) represent identical protein.


  • 形式
  • 存放说明
    Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • 纯度
    Immunogen affinity purified
  • 纯化说明
    ab120000 is purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Primary antibody说明
    Reported variants (NP_816931.1, NP_115522.1) represent identical protein.
  • 克隆
  • 同种型
  • 研究领域


Fast track antibodies constitute a diverse group of products that have been released to accelerate your research, but are not yet fully characterized. They have all been affinity purified and show high titre values against the immunizing peptide (by ELISA). Fast track terms of use

应用 Ab评论 说明
WB Use at an assay dependent concentration. Predicted molecular weight: 21 kDa. Preliminary experiments gave an approx 33kDa band in Mouse Brain lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 21.0kDa according to NP_062639.3. The 33kDa band was successfully blocked by incubation with the immunizing peptide.


  • 功能
    Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia. May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade. Isoform 2 may be required for proper retinal function and organization.
  • 疾病相关
    Defects in ARL6 are a cause of Bardet-Biedl syndrome type 3 (BBS3) [MIM:209900]. Bardet-Biedl syndrome (BBS) is a genetically heterogeneous disorder characterized by usually severe pigmentary retinopathy, early onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease.
    Defects in ARL6 are the cause of retinitis pigmentosa type 55 (RP55) [MIM:613575]. RP55 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well.
  • 序列相似性
    Belongs to the small GTPase superfamily. Arf family.
  • 细胞定位
    Cell projection > cilium membrane. Cytoplasm > cytoskeleton > cilium axoneme. Cytoplasm > cytoskeleton > cilium basal body. Appears in a pattern of punctae flanking the microtubule axoneme that likely correspond to small membrane-associated patches. Localizes to the so-called ciliary gate where vesicles carrying ciliary cargo fuse with the membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADP ribosylation factor like 6 antibody
    • ADP ribosylation factor like protein 6 antibody
    • ADP-ribosylation factor-like protein 6 antibody
    • Arl6 antibody
    • ARL6_HUMAN antibody
    • Bardet Biedl syndrome 3 protein antibody
    • Bardet-Biedl syndrome 3 protein antibody
    • BBS3 antibody
    • MGC32934 antibody
    see all


Anti-ARL6 antibody (ab120000)参考文献

ab120000 has not yet been referenced specifically in any publications.

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