概述

  • 产品名称Anti-ARL2抗体- N-terminal
    参阅全部 ARL2 一抗
  • 描述
    兔多克隆抗体to ARL2 - N-terminal
  • 经测试应用适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
  • 阳性对照
    • Hela cell line lysate.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: PBS
  • Concentration information loading...
  • 纯度Protein G purified
  • 纯化说明ab71288 is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

相关产品

应用

Our Abpromise guarantee covers the use of ab71288 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA 1/1000.
WB 1/100 - 1/500. Detects a band of approximately 21 kDa (predicted molecular weight: 21 kDa).

靶标

  • 功能Small GTP-binding protein which cycles between an inactive GDP-bound and an active GTP-bound form, and the rate of cycling is regulated by guanine nucleotide exchange factors (GEF) and GTPase-activating proteins (GAP). GTP-binding protein that does not act as an allosteric activator of the cholera toxin catalytic subunit. Regulates formation of new microtubules and centrosome integrity. Prevents the TBCD-induced microtubule destruction. Participates in association with TBCD, in the disassembly of the apical junction complexes. Antagonizes the effect of TBCD on epithelial cell detachment and tight and adherens junctions disassembly. Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. Component of a regulated secretory pathway involved in Ca(2+)-dependent release of acetylcholine. Required for normal progress through the cell cycle.
  • 序列相似性Belongs to the small GTPase superfamily. Arf family.
  • 翻译后修饰Not N-myristoylated.
  • 细胞定位Mitochondrion intermembrane space. Cytoplasm > cytoskeleton > centrosome. Nucleus. Cytoplasm. The complex formed with ARL2BP, ARL2 and SLC25A6 is expressed in mitochondria. The complex formed with ARL2BP, ARL2 and SLC25A4 is expressed in mitochondria (By similarity). Not detected in the Golgi, nucleus and on the mitotic spindle. Centrosome-associated throughout the cell cycle. Not detected to interphase microtubules.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADP ribosylation factor like 2 antibody
    • ADP-ribosylation factor-like protein 2 antibody
    • ARFL2 antibody
    • Arl184 antibody
    • Arl2 antibody
    • ARL2_HUMAN antibody
    see all

Anti-ARL2 antibody - N-terminal 图像

  • Anti-ARL2 antibody - N-terminal (ab71288) at 1/100 dilution + Hela cell line lysate at 35 µg/ml

    Predicted band size : 21 kDa
    Observed band size : 21 kDa
    Additional bands at : 32 kDa,56 kDa. We are unsure as to the identity of these extra bands.

Anti-ARL2 antibody - N-terminal (ab71288)参考文献

This product has been referenced in:
  • Price HP  et al. The small GTPase ARL2 is required for cytokinesis in Trypanosoma brucei. Mol Biochem Parasitol 173:123-31 (2010). Read more (PubMed: 20653091) »

See 1 Publication for this product

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