概述

  • 产品名称Anti-ARL13B抗体
    参阅全部 ARL13B 一抗
  • 描述
    兔多克隆抗体to ARL13B
  • 经测试应用适用于: WB, IHC-Pmore details
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rabbit, Chicken, Guinea pig, Cow, Cat, Dog
  • 免疫原

    A synthetic peptide corresponding to a region within the internal sequence amino acids 251-300 (VEPLNIDDCA PESPTPPPPP PPVGWGTPKV TRLPKLEPLG ETHHNDFYRK) of Human ARL13B (NP_659433).

  • 阳性对照
    • 721_B cell lysate.

性能

应用

Our Abpromise guarantee covers the use of ab83879 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB Use a concentration of 1 µg/ml. Detects a band of approximately 40 kDa (predicted molecular weight: 49 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
IHC-P Use at an assay dependent concentration. PubMed: 21935430

靶标

  • 疾病相关Defects in ARL13B are the cause of Joubert syndrome type 8 (JBTS8) [MIM:612291]. JBTS is an autosomal recessive disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. Neuroradiologically, it is characterized by cerebellar vermis hypoplasia/aplasia, thickened and reoriented superior cerebellar peduncles, and an abnormally large interpeduncular fossa, giving the appearance of a molar tooth on transaxial slices (molar tooth sign). Additional variable features include retinal dystrophy and renal disease.
  • 序列相似性Belongs to the small GTPase superfamily. Arf family.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ADP ribosylation factor like 13B antibody
    • ADP ribosylation factor like 2 like 1 antibody
    • ADP-ribosylation factor-like protein 13B antibody
    • ADP-ribosylation factor-like protein 2-like 1 antibody
    • AR13B_HUMAN antibody
    • arl13b antibody
    • ARL2-like protein 1 antibody
    • ARL2L1 antibody
    • JBTS8 antibody
    see all

Anti-ARL13B antibody 图像

  • Anti-ARL13B antibody (ab83879) at 1 µg/ml (HRP conjugated anti-Rabbit IgG ) + 721_B cell lysate at 10 µg

    Secondary
    5% skim milk / PBS buffer at 1/50000 dilution

    Predicted band size : 49 kDa
    Observed band size : 40 kDa (why is the actual band size different from the predicted?)

Anti-ARL13B antibody (ab83879)参考文献

This product has been referenced in:
  • Sánchez de Diego A  et al. Dido3-dependent HDAC6 targeting controls cilium size. Nat Commun 5:3500 (2014). IF ; Mouse . Read more (PubMed: 24667272) »
  • Zhang Z  et al. Fuz Regulates Craniofacial Development through Tissue Specific Responses to Signaling Factors. PLoS One 6:e24608 (2011). IHC-P ; Mouse . Read more (PubMed: 21935430) »

See all 2 Publications for this product

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