The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/10 - 1/50.
1/50 - 1/100. Detects a band of approximately 55 kDa (predicted molecular weight: 61 kDa).
功能Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.
组织特异性Detected in brain. Detected at low levels in heart.
疾病相关Defects in ARHGEF9 are a cause of startle disease with epilepsy (STHEE) [MIM:300607]; also known as hyperekplexia with epilepsy. Startle disease is a genetically heterogeneous neurologic disorder. STHE is characterized by muscular rigidity of central nervous system origin, particularly in the neonatal period, and by an exaggerated startle response to unexpected acoustic or tactile stimuli.
ab71350 at 1/10 dilution, staining ARHGEF9 in human brain by Immunohistochemistry using formalin-fixed, paraffin-embedded tissue, followed by peroxidase-conjugated secondary antibody and DAB staining.
Anti-ARHGEF9 antibody - C-terminal (ab71350)参考文献
This product has been referenced in:
Simon S et al. Inter-kingdom Signaling by the Legionella Quorum Sensing Molecule LAI-1 Modulates Cell Migration through an IQGAP1-Cdc42-ARHGEF9-Dependent Pathway. PLoS Pathog11:e1005307 (2015).
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