Anti-PDZ-RhoGEF抗体(ab110059)
Key features and details
- Rabbit polyclonal to PDZ-RhoGEF
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
概述
-
产品名称
Anti-PDZ-RhoGEF抗体 -
描述
兔多克隆抗体to PDZ-RhoGEF -
宿主
Rabbit -
经测试应用
适用于: WBmore details -
种属反应性
与反应: Human
预测可用于: Mouse, Rat -
免疫原
Synthetic peptide corresponding to Human PDZ-RhoGEF (N terminal).
-
阳性对照
- A549 and COLO cell extracts.
-
常规说明
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
性能
-
形式
Liquid -
存放说明
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
存储溶液
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol (glycerin, glycerine)
PBS without Mg2+ and Ca2+ -
Concentration information loading...
-
纯度
Immunogen affinity purified -
纯化说明
ab110059 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. -
克隆
多克隆 -
同种型
IgG -
研究领域
相关产品
-
Compatible Secondaries
-
Isotype control
应用
The Abpromise guarantee
Abpromise™承诺保证使用ab110059于以下的经测试应用
“应用说明”部分 下显示的仅为推荐的起始稀释度;实际最佳的稀释度/浓度应由使用者检定。
应用 | Ab评论 | 说明 |
---|---|---|
WB |
1/500 - 1/1000. Predicted molecular weight: 168 kDa.
|
说明 |
---|
WB
1/500 - 1/1000. Predicted molecular weight: 168 kDa. |
靶标
-
功能
May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13. -
组织特异性
Ubiquitously expressed. -
序列相似性
Contains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 RGSL (RGS-like) domain. -
结构域
The poly-Pro region is essential for plasma membrane localization upon stimulation. -
细胞定位
Cytoplasm. Membrane. Translocated to the membrane upon stimulation. - Information by UniProt
-
数据库链接
- Entrez Gene: 9826 Human
- Entrez Gene: 213498 Mouse
- Entrez Gene: 78966 Rat
- Omim: 605708 Human
- SwissProt: O15085 Human
- SwissProt: Q9ES67 Rat
- Unigene: 516954 Human
- Unigene: 160580 Rat
-
别名
- ARHGB_HUMAN antibody
- ARHGEF 11 antibody
- ARHGEF11 antibody
see all
图片
数据表及文件
-
SDS download
-
Datasheet download
文献 (3)
ab110059 被引用在 3 文献中.
- Chandan NR et al. A network of Gαi signaling partners is revealed by proximity labeling proteomics analysis and includes PDZ-RhoGEF. Sci Signal 15:eabi9869 (2022). PubMed: 35041463
- Zhang W et al. Transgenerational Obesity and Alteration of ARHGEF11 in the Rat Liver Induced by Intrauterine Hyperglycemia. J Diabetes Res 2019:6320839 (2019). PubMed: 31612150
- Zhang W et al. ARHGEF11 affecting the placental insulin signaling pathway in fetal macrosomia of normal glucose tolerance pregnant women. Placenta 63:7-14 (2018). WB, IHC-P . PubMed: 29486856