概述

  • 产品名称Anti-ARHGEF1抗体
    参阅全部 ARHGEF1 一抗
  • 描述
    小鼠单克隆抗体to ARHGEF1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant fragment: CRPGPEGQLA ATALRKVLSL KQLLFPAEED NGAGPPRDGD GVPGGGPLSP ARTQEIQENL LSLEETMKQL EELEEEFCRL RPLLSQLGGN SVPQPGCT, corresponding to amino acids 830-927 of Human ARHGEF1

性能

应用

Our Abpromise guarantee covers the use of ab56462 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.
    • 组织特异性Ubiquitously expressed.
    • 序列相似性Contains 1 DH (DBL-homology) domain.
      Contains 1 PH domain.
      Contains 1 RGSL (RGS-like) domain.
    • 结构域The RGSL domain, also known as rgRGS domain, is necessary but not sufficient for GAP activity.
      The DH domain is involved in interaction with CCPG1.
    • 翻译后修饰Phosphorylated by PKCA. Angiotensin-2 induced Tyr-738 phosphorylation is mediated by JAK2.
    • 细胞定位Cytoplasm. Membrane. Translocated to the membrane by activated GNA13 or LPA stimulation.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 115 kD protein antibody
      • 115 kDa guanine nucleotide exchange factor antibody
      • ARHG1_HUMAN antibody
      • ARHGEF 1 antibody
      • ARHGEF1 antibody
      • GEF 1 antibody
      • GEF1 antibody
      • LBCL 2 antibody
      • LBCL2 antibody
      • LSC antibody
      • Lsc homolog antibody
      • p115 RhoGEF antibody
      • p115-RhoGEF antibody
      • p115RhoGEF antibody
      • Rho guanine nucleotide exchange factor (GEF) 1 antibody
      • Rho guanine nucleotide exchange factor 1 antibody
      • Sub1.5 antibody
      see all

    Anti-ARHGEF1 antibody 图像

    • Western blot against tagged recombinant protein immunogen using ab56462 ARHGEF1 antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    Anti-ARHGEF1 antibody (ab56462)参考文献

    ab56462 has not yet been referenced specifically in any publications.

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