Anti-ARH抗体- Carboxyterminal end (ab63155)


  • 产品名称Anti-ARH抗体- Carboxyterminal end
    参阅全部 ARH 一抗
  • 描述
    兔多克隆抗体to ARH - Carboxyterminal end
  • 经测试应用适用于: WB, ELISA, IHC-Pmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Synthetic peptide (Human) conjugated to KLH to the C terminal region of human ARH.

  • 阳性对照
    • NCI-H460 cell line lysates and human hepatocarcinoma tissue.



Our Abpromise guarantee covers the use of ab63155 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/50 - 1/100. Detects a band of approximately 36 kDa (predicted molecular weight: 34 kDa).
ELISA 1/1000.
IHC-P 1/50.


  • 功能Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface.
  • 组织特异性Expressed at high levels in the kidney, liver, and placenta, with lower levels detectable in brain, heart, muscle, colon, spleen, intestine, lung, and leukocytes.
  • 疾病相关Defects in LDLRAP1 are the cause of autosomal recessive hypercholesterolemia (ARH) [MIM:603813]. ARH is a disorder caused by defective internalization of LDL receptors (LDLR) in the liver. ARH has the clinical features of familial hypercholesterolemia (FH) [MIM:143890] homozygotes, including severely elevated plasma LDL cholesterol, tuberous and tendon xanthomata, and premature atherosclerosis. LDL receptor (LDLR) activity measured in skin fibroblasts is normal, as the LDL binding ability.
  • 序列相似性Contains 1 PID domain.
  • 结构域The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.
  • 翻译后修饰Phosphorylated upon DNA damage, probably by ATM or ATR.
  • 细胞定位Cytoplasm.
  • Information by UniProt
  • 数据库链接
  • 别名
    • ARH antibody
    • ARH GENE antibody
    • ARH_HUMAN antibody
    • ARH1 antibody
    • ARH2 antibody
    • Autosomal recessive hypercholesterolemia protein antibody
    • DKFZp586D0624 antibody
    • FHCB1 antibody
    • FHCB2 antibody
    • LDL receptor adaptor protein antibody
    • Ldlrap1 antibody
    • Low density lipoprotein receptor adapter protein 1 antibody
    • MGC34705 antibody
    • OTTHUMP00000008526 antibody
    see all

Anti-ARH antibody - Carboxyterminal end 图像

  • Anti-ARH antibody - Carboxyterminal end (ab63155) at 1/60 dilution + NCI-H460 cell line lysates at 35 µg

    Predicted band size : 34 kDa
    Observed band size : 36 kDa (why is the actual band size different from the predicted?)
  • Immunohistochemical analysis of ARH expression in formalin fixed, paraffin embedded human hepatocarcinoma tissue using 1/50 ab63155, followed by peroxidase-conjugated secondary antibody step and DAB staining.

Anti-ARH antibody - Carboxyterminal end (ab63155)参考文献

ab63155 has not yet been referenced specifically in any publications.

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