Anti-Argininosuccinate Lyase抗体(ab96215)

概述

  • 产品名称Anti-Argininosuccinate Lyase抗体
    参阅全部 Argininosuccinate Lyase 一抗
  • 描述
    兔多克隆抗体to Argininosuccinate Lyase
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Cow
  • 免疫原

    Recombinant fragment, corresponding to a region within amino acids 86-335 of Human Argininosuccinate Lyase.

  • 阳性对照
    • 293T, A431, H1299, HeLa, HepG2, MOLT4 and Raji cells

性能

应用

Our Abpromise guarantee covers the use of ab96215 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/500 - 1/3000. Predicted molecular weight: 52 kDa.

靶标

  • 通路Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3.
    Nitrogen metabolism; urea cycle; L-arginine and fumarate from (N(omega)-L-arginino)succinate: step 1/1.
  • 疾病相关Defects in ASL are the cause of arginosuccinicaciduria (ARGINSA) [MIM:207900]. Arginosuccinicaciduria is an autosomal recessive disorder of the urea cycle. The disease is characterized by mental and physical retardation, liver enlargement, skin lesions, dry and brittle hair showing trichorrhexis nodosa microscopically and fluorescing red, convulsions, and episodic unconsciousness.
  • 序列相似性Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.
  • 翻译后修饰Acetylation modifies enzyme activity in response to alterations of extracellular nutrient availability. Acetylation increased with trichostin A (TSA) or with nicotinamide (NAM). Glucose increases acetylation by about a factor of 3 with decreasing enzyme activity. Acetylation on Lys-288 is decreased on the addition of extra amino acids resulting in activation of enzyme activity.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Argininosuccinase antibody
    • Argininosuccinate lyase antibody
    • Arginosuccinase antibody
    • ARLY_HUMAN antibody
    • ASAL antibody
    • ASL antibody
    • EC 4.3.2.1 antibody
    see all

Anti-Argininosuccinate Lyase antibody 图像

  • Anti-Argininosuccinate Lyase antibody (ab96215) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

    Predicted band size : 52 kDa

Anti-Argininosuccinate Lyase antibody (ab96215)参考文献

ab96215 has not yet been referenced specifically in any publications.

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