Recombinant fragment: KVESPGTYQQ DPWAMTDEEK AKAVPLIHQE GNRLYREGHV KEAAAKYYDA ACLKNLQMKE QPGSPEWIQL DKQITPLLLN YCQCKLVVEE YYE, corresponding to amino acids 156-250 of Human ARA9 (NP_003968) with a 26 kDa tag
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 38 kDa.
Use at an assay dependent dilution.
功能May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein.
组织特异性Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver.
疾病相关Defects in AIP are a cause of familial isolated pituitary adenoma (FIPA) [MIM:102200]. Defects in AIP are a cause of growth hormone-secreting pituitary adenoma (GHSPA) [MIM:102200]; also known as familial isolated somatotropinomas (FIS) or isolated familial somatotropinoma (IFS) or familial somatotrophinoma or acromegaly due to pituitary adenoma. Defects in AIP are a cause of ACTH-secreting pituitary adenoma (ASPA) [MIM:219090]; also known as pituitary Cushing disease. A pituary adenoma resulting in excessive production of adrenocorticotropic hormone. This leads to hypersecretion of cortisol by the adrenal glands and ACTH-dependent Cushing syndrome. Clinical manifestations of Cushing syndrome include facial and trunkal obesity, abdominal striae, muscular weakness, osteoporosis, arterial hypertension, diabetes. Defects in AIP are a cause of prolactin-secreting pituitary adenoma (PSPA) [MIM:600634]; also known as prolactinoma. Prolactin-secreting pituitary adenoma is the most common type of hormonally active pituitary adenoma.
Anti-ARA9 antibody (ab88470) at 1 µg/ml + HepG2 cell lysate at 50 µg
Secondary Goat Anti-Mouse IgG at 1/5000 dilution
Predicted band size : 38 kDa
Anti-ARA9 antibody (ab88470)参考文献
This product has been referenced in:
Zhou Q et al. Aryl Hydrocarbon Receptor Interacting Protein Targets IRF7 to Suppress Antiviral Signaling and the Induction of Type I Interferon. J Biol Chem290:14729-39 (2015).
Read more (PubMed: 25911105) »