Anti-Aquaporin 4抗体(ab15118)

概述

  • 产品名称Anti-Aquaporin 4抗体
    参阅全部 Aquaporin 4 一抗
  • 描述
    兔多克隆抗体to Aquaporin 4
  • 特异性The 17 AA rat AQP41 peptide was found to be unique to AQP4.
  • 经测试应用适用于: WB, ELISAmore details
  • 种属反应性
    与反应: Rat
    预测可用于: Mouse
  • 免疫原

    Synthetic peptide (Rat) conjugated to KLH (C terminal).

  • 阳性对照
    • Rat cerebellum.

性能

应用

Our Abpromise guarantee covers the use of ab15118 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
ELISA
  • 应用说明ELISA: 1/10000 - 1/50000.
    WB: 1/1000 - 1/5000. Predicted molecular weight: 35 kDa. Note: Recommend the use of 0.5-1% milk in all primary/secondary antibody-enzyme conjugate incubations in order to suppress non-specific bands.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system.
    • 组织特异性Brain - muscle >> heart, kidney, lung, and trachea.
    • 序列相似性Belongs to the MIP/aquaporin (TC 1.A.8) family.
    • 结构域Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
    • 翻译后修饰Phosphorylation by PKC at Ser-180 reduces conductance by 50%. Phosphorylation by PKG at Ser-111 in response to glutamats increases conductance by 40%.
    • 细胞定位Membrane.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AQP 4 antibody
      • AQP-4 antibody
      • AQP4 antibody
      • AQP4_HUMAN antibody
      • Aquaporin type 4 antibody
      • Aquaporin-4 antibody
      • Aquaporin4 antibody
      • HMIWC 2 antibody
      • HMIWC2 antibody
      • Mercurial insensitive water channel antibody
      • Mercurial-insensitive water channel antibody
      • MGC22454 antibody
      • MIWC antibody
      • WCH 4 antibody
      • WCH4 antibody
      see all

    Anti-Aquaporin 4 antibody (ab15118)参考文献

    ab15118 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your enquiry. I can't find any reference to a glycosylated 52KD form. I checked with our source for this antibody and he said he did not either; he "found literature on the Internet that glycosylation of Aquaporin 4 can occur at a motif n...

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    Dear Dr Lovatt; Thank you for your enquiry. We do not have any specific information regarding the epitope that this product recognises. The aa sequence indicates an intracellular epitope. If you need any further assistance please do not hesitate to ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"