概述
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产品名称Anti-Aquaporin 2抗体
参阅全部 Aquaporin 2 一抗 -
描述兔多克隆抗体to Aquaporin 2
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宿主Rabbit
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经测试应用适用于: WB, ELISA, IHC-Pmore details
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种属反应性与反应: Human
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免疫原
Synthetic peptide corresponding to N-terminal residues of human Aquaporin 2
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阳性对照
- human Kidney
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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存储溶液Preservative: 0.01% Sodium Azide
Constituents: 50% Glycerol, PBS -
Concentration information loading... -
纯度Immunogen affinity purified
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
应用
Our Abpromise guarantee covers the use of ab78230 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| WB | Use a concentration of 1 µg/ml. Predicted molecular weight: 29 kDa. | |
| ELISA | Use a concentration of 1 µg/ml. | |
| IHC-P | Use a concentration of 20 µg/ml. |
靶标
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功能Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
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组织特异性Expressed in renal collecting tubules.
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疾病相关Diabetes insipidus, nephrogenic, autosomal
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序列相似性Belongs to the MIP/aquaporin (TC 1.A.8) family.
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结构域Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
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翻译后修饰Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
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细胞定位Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
- Information by UniProt
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数据库链接
- Entrez Gene: 359 Human
- Omim: 107777 Human
- SwissProt: P41181 Human
- Unigene: 130730 Human
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别名
- ADH water channel antibody
- AQP 2 antibody
- AQP CD antibody
see all
图片
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Aquaporin 2 antibody (ab78230)Immunohistochemical analysis of acquaporin 2 expression in Formalin-Fixed Paraffin Embedded human kidney using 20 µg/ml ab78230
文献
ab78230 has not yet been referenced specifically in any publications.
客户评价及客户问答
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"