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功能
Forms a water-specific channel that provides the plasma membranes of renal collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
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组织特异性
Expressed in renal collecting tubules.
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疾病相关
Diabetes insipidus, nephrogenic, autosomal
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序列相似性
Belongs to the MIP/aquaporin (TC 1.A.8) family.
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结构域
Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
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翻译后修饰
Ser-256 phosphorylation is necessary and sufficient for expression at the apical membrane. Endocytosis is not phosphorylation-dependent.
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细胞定位
Apical cell membrane. Basolateral cell membrane. Cytoplasmic vesicle membrane. Golgi apparatus, trans-Golgi network membrane. Shuttles from vesicles to the apical membrane. Vasopressin-regulated phosphorylation is required for translocation to the apical cell membrane. PLEKHA8/FAPP2 is required to transport AQP2 from the TGN to sites where AQP2 is phosphorylated.
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Information by UniProt
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数据库链接
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别名
- ADH water channel antibody
- AQP 2 antibody
- AQP CD antibody
- AQP-2 antibody
- AQP-CD antibody
- AQP2 antibody
- AQP2_HUMAN antibody
- AQPCD antibody
- Aquaporin 2 collecting duct antibody
- Aquaporin CD antibody
- Aquaporin-2 antibody
- Aquaporin-CD antibody
- Aquaporin2 antibody
- Aquaporine 2 antibody
- Collecting duct water channel protein antibody
- MGC34501 antibody
- Water channel aquaporin 2 antibody
- Water channel protein for renal collecting duct antibody
- WCH CD antibody
- WCH-CD antibody
- WCHCD antibody
see all