概述

  • 产品名称Anti-Aquaporin 1抗体[1/A5F6]
    参阅全部 Aquaporin 1 一抗
  • 描述
    小鼠单克隆抗体[1/A5F6] to Aquaporin 1
  • 经测试应用适用于: Flow Cyt, IHC-Fr, IHC-P, ELISA, WBmore details
  • 种属反应性
    与反应: Mouse, Rat, Human
  • 免疫原

    Synthetic peptide, corresponding to amino acids 249 - 269 of Rat Aquaporin 1.

  • 表位ab11023 recognises an epitope within the cytoplasmic domain of the water-specific channel aquaporin 1
  • 阳性对照
    • Kidney.
  • 常规说明This product should be stored undiluted. Storage in frost-free freezers is not recommended. Should this product contain a precipitate we recommend microcentrifugation before use.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
  • 存储溶液Preservative: 0.09% Sodium Azide
    Constituents: 1% BSA
  • Concentration information loading...
  • 纯度Protein G purified
  • 克隆单克隆
  • 克隆编号1/A5F6
  • 骨髓瘤Sp2/0-Ag14
  • 同种型IgG1
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab11023 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
Flow Cyt Use at an assay dependent concentration. PubMed: 24376529

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

IHC-Fr 1/500.
IHC-P 1/500. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.
ELISA 1/1000.
WB 1/1000. Predicted molecular weight: 28 kDa.

靶标

  • 功能Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
  • 组织特异性Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver.
  • 序列相似性Belongs to the MIP/aquaporin (TC 1.A.8) family.
  • 结构域Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).
  • 细胞定位Membrane.
  • Information by UniProt
  • 数据库链接
  • 别名
    • AQP 1 antibody
    • AQP CHIP antibody
    • AQP-1 antibody
    • AQP1 antibody
    • AQP1_HUMAN antibody
    • aquaporin 1 (channel-forming integral protein, 28kDa, CO blood group) antibody
    • aquaporin 1 (Colton blood group) antibody
    • Aquaporin CHIP antibody
    • Aquaporin-1 antibody
    • Aquaporin-CHIP antibody
    • Aquaporin1 antibody
    • Channel forming integral protein 28kDa antibody
    • Channel like integral membrane protein 28 kDa antibody
    • CHIP 28 antibody
    • CHIP28 antibody
    • CO antibody
    • Colton blood group antibody
    • Growth factor induced delayed early response protein antibody
    • MGC26324 antibody
    • Urine water channel antibody
    • Water channel protein CHIP 29 antibody
    • Water channel protein CHIP29 antibody
    • Water channel protein for red blood cells and kidney proximal tubule antibody
    see all

Anti-Aquaporin 1 antibody [1/A5F6] (ab11023)参考文献

This product has been referenced in:
  • Fontijn RD  et al. Expression of Nitric Oxide-Transporting Aquaporin-1 Is Controlled by KLF2 and Marks Non-Activated Endothelium In Vivo. PLoS One 10:e0145777 (2015). IHC-P ; Human . Read more (PubMed: 26717516) »
  • Azouzi S  et al. Energetic and molecular water permeation mechanisms of the human red blood cell urea transporter B. PLoS One 8:e82338 (2013). Flow Cyt ; Human . Read more (PubMed: 24376529) »

See all 2 Publications for this product

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