概述

  • 产品名称
    Anti-Aquaporin 0抗体
    参阅全部 Aquaporin 0 一抗
  • 描述
    兔多克隆抗体to Aquaporin 0
  • 特异性
    ab15077 recognises aquaporin 0.
  • 经测试应用
    适用于: ELISA, WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Rat, Cow
  • 免疫原

    A 17 AA synthetic peptide within the carboxy terminal domain of human Aquaporin 0.

性能

应用

Our Abpromise guarantee covers the use of ab15077 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
ELISA
WB
  • 应用说明
    ELISA: Use at a concentration of 0.5 - 1 µg/ml.
    WB: Use at a concentration of 1 - 10 µg/ml with ECL detection. Predicted molecular weight: 28 kDa.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能
      Water channel. May be responsible for regulating the osmolarity of the lens. Interactions between homotetramers from adjoining membranes may stabilize cell junctions in the eye lens core.
    • 组织特异性
      Major component of lens fiber gap junctions.
    • 疾病相关
      Cataract 15, multiple types
    • 序列相似性
      Belongs to the MIP/aquaporin (TC 1.A.8) family.
    • 结构域
      Aquaporins contain two tandem repeats each containing two membrane-spanning helices and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). Each tandem repeat contains a loop and a short helix that enter and leave the lipid bilayer on the same side.
    • 翻译后修饰
      Subject to partial proteolytic cleavage in the eye lens core. Partial proteolysis promotes interactions between tetramers from adjoining membranes.
    • 细胞定位
      Cell membrane. Cell junction > gap junction.
    • Information by UniProt
    • 数据库链接
    • 别名
      • AQP 0 antibody
      • AQP0 antibody
      • Aquaporin antibody
      • Aquaporin-0 antibody
      • Aquaporin0 antibody
      • Lens fiber major intrinsic protein antibody
      • LIM 1 antibody
      • LIM1 antibody
      • Major intrinsic protein 26kD antibody
      • Major intrinsic protein of lens fiber antibody
      • MIP 26 antibody
      • mip antibody
      • MIP_HUMAN antibody
      • MIP26 antibody
      • MP 26 antibody
      • MP26 antibody
      • PALM antibody
      see all

    实验方案

    文献

    This product has been referenced in:
    • Chaffee BR  et al. FGFR and PTEN signaling interact during lens development to regulate cell survival. Dev Biol 410:150-163 (2016). Read more (PubMed: 26764128) »
    • Tan H  et al. Critical role of inflammatory cytokines in impairing biochemical processes for learning and memory after surgery in rats. J Neuroinflammation 11:93 (2014). Read more (PubMed: 24884762) »

    See all 4 Publications for this product

    客户评价及客户问答

    いつもお世話になっております。 この度はお問合せいただきましてありがとうございます。 申し訳ありませんが、ab15077のpositive controlを取り扱いしておりません。しかしながら、bovine lens fiberはpositive controlとしてご使用できます。 もしよければ、この抗体や、似ているクローンの文献情報は以下に添付いたします。 Molecular Vision 2003; 9:497-501 [http://www.molvis.org/mo...

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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