概述

  • 产品名称Anti-APPD抗体
    参阅全部 APPD 一抗
  • 描述
    兔多克隆抗体to APPD
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
    预测可用于: Mouse, Rat, Cow, Dog
  • 免疫原

    Synthetic peptide conjugated to KLH, corresponding to a region between amino acids 243-257 of Human APPD.

  • 阳性对照
    • HeLa whole cell lysate.
  • 常规说明


    APPD is predicted through gene annotation and contains pleckstrin homology domain. It may binds to two Zn++ ions through its FYVE zinc finger domain. Biological function of this protein has not been clearly mapped yet.

性能

  • 形式Liquid
  • 存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • 存储溶液Preservative: None
    Constituents: PBS, Sucrose
  • Concentration information loading...
  • 纯度Protein A purified
  • Primary antibody说明APPD is predicted through gene annotation and contains pleckstrin homology domain. It may binds to two Zn++ ions through its FYVE zinc finger domain. Biological function of this protein has not been clearly mapped yet.
  • 克隆多克隆
  • 同种型IgG
  • 研究领域

应用

Our Abpromise guarantee covers the use of ab10081 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB 1/1000. Detects a band of approximately 31 kDa (predicted molecular weight: 33.5 kDa). Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.

靶标

  • 功能May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
  • 组织特异性Highly expressed in heart and skeletal muscle. Weakly expressed in brain, thymus, spleen, kidney, liver, small intestine, placenta and lung.
  • 序列相似性Contains 1 FYVE-type zinc finger.
    Contains 1 PH domain.
  • 结构域PH and FYVE-type zinc finger domains are required for lysosomal location.
  • 细胞定位Nucleus. Cytoplasm > perinuclear region. Lysosome. Translocates to lysosome during apoptosis.
  • Information by UniProt
  • 数据库链接
  • 别名
    • Apoptosis inducing protein antibody
    • Apoptosis inducing protein D antibody
    • Apoptosis-inducing protein antibody
    • LAPF antibody
    • Lysosome associated apoptosis inducing protein containing PH and FYVE domains antibody
    • Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains antibody
    • MGC4090 antibody
    • PH and FYVE domain containing protein 1 antibody
    • PH and FYVE domain-containing protein 1 antibody
    • PH domain containing family F member 1 antibody
    • PH domain-containing family F member 1 antibody
    • Phafin 1 antibody
    • Phafin-1 antibody
    • Phafin1 antibody
    • PKHF1_HUMAN antibody
    • Pleckstrin homology domain containing family F (with FYVE domain) member 1 antibody
    • Pleckstrin homology domain containing family F member 1 antibody
    • Pleckstrin homology domain containing family F with FYVE domain member 1 antibody
    • Pleckstrin homology domain-containing family F member 1 antibody
    • PLEKHF 1 antibody
    • Plekhf1 antibody
    • ZFYVE 15 antibody
    • ZFYVE15 antibody
    • Zinc finger FYVE domain containing protein 15 antibody
    • Zinc finger FYVE domain-containing protein 15 antibody
    see all

Anti-APPD antibody 图像



  • Predicted band size : 33.5 kDa


    ab10081 at 1/1000 dilution staining approximately 31kDa band of human APPD in Hela whole cell lysate by Western blot (ECL).

Anti-APPD antibody (ab10081)参考文献

ab10081 has not yet been referenced specifically in any publications.

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