概述

  • 产品名称Anti-APPBP1抗体
    参阅全部 APPBP1 一抗
  • 描述
    小鼠单克隆抗体to APPBP1
  • 经测试应用适用于: WBmore details
  • 种属反应性
    与反应: Human
  • 免疫原

    Recombinant full length protein, corresponding to amino acids 1-535 of Human APPBP1

性能

应用

Our Abpromise guarantee covers the use of ab56420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
WB
  • 应用说明WB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • 靶标

    • 功能Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
    • 组织特异性Ubiquitous in fetal tissues. Expressed throughout the adult brain.
    • 通路Protein modification; protein neddylation.
    • 序列相似性Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
    • 细胞定位Cell membrane. Colocalizes with APP in lipid rafts.
    • Information by UniProt
    • 数据库链接
    • 别名
      • 59 kDa antibody
      • A 116A10.1 antibody
      • Amyloid beta precursor protein binding protein 1 59kD antibody
      • Amyloid beta precursor protein binding protein 1 59kDa antibody
      • Amyloid beta precursor protein binding protein 1 antibody
      • Amyloid beta precursor protein binding protein 1, 59 kDa antibody
      • Amyloid beta precursor protein-binding protein 1 antibody
      • Amyloid protein binding protein 1 antibody
      • Amyloid protein-binding protein 1 antibody
      • APP BP1 antibody
      • APP-BP1 antibody
      • APPBP 1 antibody
      • APPBP1 antibody
      • HPP 1 antibody
      • HPP1 antibody
      • NAE 1 antibody
      • NAE1 antibody
      • NEDD8 activating enzyme E1 regulatory subunit antibody
      • NEDD8 activating enzyme E1 subunit 1 antibody
      • NEDD8 activating enzyme E1 subunit antibody
      • NEDD8-activating enzyme E1 regulatory subunit antibody
      • Proto oncogene protein 1 antibody
      • Proto-oncogene protein 1 antibody
      • Protooncogene protein 1 antibody
      • ula 1 antibody
      • ULA1_HUMAN antibody
      see all

    Anti-APPBP1 antibody 图像



    • Predicted band size : 60 kDa
      APPBP1 antibody (ab56420) at 1ug/lane + HeLa cell lysate at 25ug/lane.

    Anti-APPBP1 antibody (ab56420)参考文献

    ab56420 has not yet been referenced specifically in any publications.

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