Anti-Apoptosis抑制剂5抗体(ab99308)

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概述

  • 产品名称
    Anti-Apoptosis抑制剂5抗体
    参阅全部 Apoptosis inhibitor 5 一抗
  • 描述
    兔多克隆抗体to Apoptosis抑制剂5
  • 宿主
    Rabbit
  • 经测试应用
    适用于: IHC-P, IPmore details
    不适用于: WB
  • 种属反应性
    与反应: Mouse, Human
    预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • 免疫原

    Immunogen correspondsto a region within amino acids 150-200 of Human Apoptosis inhibitor 5 (XP_508375.2).

  • 阳性对照
    • Hela whole cell lysate

性能

应用

Our Abpromise guarantee covers the use of ab99308 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

应用 Ab评论 说明
IHC-P Use at an assay dependent concentration.
IP Use at 2-5 µg/mg of lysate.
  • 应用说明
    Is unsuitable for WB.

    • 靶标

    • 功能
      Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
    • 组织特异性
      Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
    • 序列相似性
      Belongs to the API5 family.
    • 结构域
      Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
    • 细胞定位
      Cytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
    • Information by UniProt
    • 数据库链接
      • 别名
        • AAC 11 antibody
        • AAC-11 antibody
        • AAC11 antibody
        • Antiapoptosis clone 11 protein antibody
        • API 5 antibody
        • API-5 antibody
        • api5 antibody
        • API5 like 1 antibody
        • API5_HUMAN antibody
        • API5L1 antibody
        • Apoptosis inhibitor 5 antibody
        • Cell migration inducing gene 8 protein antibody
        • Cell migration-inducing gene 8 protein antibody
        • Fibroblast growth factor 2 interacting factor 2 antibody
        • Fibroblast growth factor 2-interacting factor antibody
        • FIF antibody
        • MIG 8 antibody
        • MIG8 antibody
        • Migration inducing protein MIG8 antibody
        • Protein XAGL antibody
        see all

      图片

      • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apoptosis inhibitor 5 antibody (ab99308)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apoptosis inhibitor 5 antibody (ab99308)
        Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma (left) and mouse teratoma (right) tissues labelling Apoptosis inhibitor 5 with ab99308 at 1/5000 (0.2µg/mg). Detection: DAB.
      • Immunoprecipitation - Apoptosis inhibitor 5 antibody (ab99308)
        Immunoprecipitation - Apoptosis inhibitor 5 antibody (ab99308)
        anti Apoptosis inhibitor 5 (ab99307), at 0.4 µg/ml, staining Apoptosis inhibitor 5 in HeLa whole cell lysate immunoprecipitated using ab99308 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
        Detection: Chemiluminescence with an exposure time of 1 second.

      文献

      ab99308 has not yet been referenced specifically in any publications.

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