概述
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产品名称Anti-Apoptosis inhibitor 5抗体
参阅全部 Apoptosis inhibitor 5 一抗 -
描述兔多克隆抗体to Apoptosis inhibitor 5
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经测试应用适用于: IHC-P, IPmore details
不适用于: WB -
种属反应性与反应: Mouse, Human
预测可用于: Rat, Rabbit, Horse, Guinea pig, Cow, Dog, Pig, Chimpanzee, Rhesus monkey, Gorilla, Orangutan
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免疫原
Immunogen correspondsto a region within amino acids 150-200 of Human Apoptosis inhibitor 5 (XP_508375.2).
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阳性对照
- Hela whole cell lysate
性能
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形式Liquid
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存放说明Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
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存储溶液Preservative: 0.09% Sodium Azide
Constituents: Tris citrate/phosphate, pH 7-8 -
Concentration information loading... -
纯度Immunogen affinity purified
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纯化说明ab99308 was affinity purified using an epitope specific to Apoptosis inhibitor 5 immobilized on solid support.
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克隆多克隆
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同种型IgG
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研究领域
相关产品
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Compatible Secondaries
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Positive Controls
应用
Our Abpromise guarantee covers the use of ab99308 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| 应用 | Ab评论 | 说明 |
|---|---|---|
| IHC-P | Use at an assay dependent concentration. | |
| IP | Use at 2-5 µg/mg of lysate. |
应用说明
Is unsuitable for WB.
靶标
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功能Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
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组织特异性Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
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序列相似性Belongs to the API5 family.
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结构域Two regions, an N-terminal (aa 96-107) and a C-terminal (aa 274-311) are required for binding FGF2.
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细胞定位Cytoplasm and Nucleus. Cytoplasm. Mainly nuclear. Can also be cytoplasmic.
- Information by UniProt
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数据库链接
- Entrez Gene: 8539 Human
- Entrez Gene: 11800 Mouse
- Omim: 609774 Human
- SwissProt: Q9BZZ5 Human
- SwissProt: O35841 Mouse
- Unigene: 435771 Human
- Unigene: 181824 Mouse
- Unigene: 402557 Mouse
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别名
- AAC 11 antibody
- AAC-11 antibody
- AAC11 antibody
see all
Anti-Apoptosis inhibitor 5 antibody 图像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Apoptosis inhibitor 5 antibody (ab99308)Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma (left) and mouse teratoma (right) tissues labelling Apoptosis inhibitor 5 with ab99308 at 1/5000 (0.2µg/mg). Detection: DAB. -
Immunoprecipitation - Apoptosis inhibitor 5 antibody (ab99308)anti Apoptosis inhibitor 5 (ab99307), at 0.4 µg/ml, staining Apoptosis inhibitor 5 in HeLa whole cell lysate immunoprecipitated using ab99308 at 3 µg/mg lysate (1 mg/IP; 20% of IP loaded/lane).
Detection: Chemiluminescence with an exposure time of 1 second.
Anti-Apoptosis inhibitor 5 antibody (ab99308)参考文献
ab99308 has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"